Monday, 28 November 2011

Barcelona's 27-game run ends

Angel Di Maria

updated 6:17 p.m. ET Nov. 26, 2011

MADRID - Getafe ended Barcelona's 27-game unbeaten streak, shocking the Spanish champions 1-0 as Juan Valera scored in the 67th minute with a header off a corner kick.

Real Madrid opened a six-point lead, coming from behind to beat Atletico Madrid 4-1 as Cristiano Ronaldo converted a pair of penalty kicks and Angel Di Maria and Gonzalo Higuain scored one goal apiece. Real has won nine straight league games and maintained a 12-year unbeaten run in the Spanish-capital derby.

Barcelona had not lost since April 30, starting this season unbeaten in 21 matches, and the overall unbeaten streak was one shy of the club record set from September to January last season. Barcelona's Lionel Messi had a goal disallowed for offside in second-half injury time, then hit a post just before the final whistle.

___

LONDON (AP) ? Manchester United was held to a 1-1 draw at home by Newcastle, costing the defending champions in their bid to catch first-place Manchester City in the Premier League.

A disputed foul allowed Demba Ba to tie the score on a 61st-minute penalty kick for Newcastle at Old Trafford. Javier Hernandez put United ahead in the 49th.

United is four points behind City, which plays Liverpool on Sunday. Third-place Tottenham closed within two points of United with a 3-1 win at West Bromwich Albion.

Ba's ninth league goal of the season came after Rio Ferdinand fouled Hatem Ben Arfa with what looked to be a legal challenge.

Emmanuel Adebayor scored twice in Tottenham's club-record fifth straight Premier League win. Chelsea scored three times in the first half for a 3-0 victory over Wolverhampton.

Arsenal slipped two points behind Chelsea after defender Thomas Vermaelen scored a goal and gave up an own-goal in a 1-1 draw against Fulham. Wigan beat Sunderland 2-1 and was replaced at the bottom of the standings by Blackburn, which lost 3-1 at Stoke.

___

MILAN (AP) ? Simone Pepe scored in the 34th minute to give Juventus a 1-0 win at Lazio in a clash between the top two Serie A teams.

The midfielder scored with a crisp shot from the center of the area to give Juventus a one-point lead in the standings. Udinese is next after beating Roma 2-0 on Friday but has played one match more, as has Lazio.

___

BERLIN (AP) ? Borussia Dortmund took the lead in the German league, defeating rival Schalke 2-0 win. Dortmund had not beaten Schalke at home since 2007 but has now won seven of its last eight Bundesliga games.

With Bayern Munich idle until it plays at Mainz on Sunday, Robert Lewandowski scored in the 16th minute for the defending champions and Felipe Santana provided an an insurance goal in the 61st.

Pierre-Michel Lasogga's second goal gave Hertha Berlin a 3-3 draw with Bayer Leverkusen after having lost a two-goal lead. Eren Derdiyok scored a hat trick for Leverkusen.

U.S. defender Timmy Chandler scored for Nuremberg, which beat Kaiserslautern 1-0. Chandler's second Bundesliga goal came after a strong run into the penalty area in the 14th minute. Chandler, who also scored Feb. 12 against Stuttgart, gained possession from Alexander Bugera, then cut inside and hit a left-footed shot from just inside the penalty area.

Hoffenheim drew 1-1 with Freiburg. Robert Firmino scored the opening goal for Hoffenheim in the 24th after playing down a high ball from American midfielder Fabian Johnson. Last-place Augsburg defeated Wolfsburg 2-0. Hamburger SV drew 1-1 at Hannover, extending manager Thorsten Fink's unbeaten run in all competitions since taking over the then-last-place club last month.

___

PARIS (AP) ? Olivier Giroud's hat trick led Montpellier to a 3-1 win at Sochaux, keeping the pressure on Paris Saint-Germain at the top of the French league.

Montpellier is in front by three points. PSG plays at rival Marseille on Sunday.

Giroud opened the scoring in the 50th minute. Abdoul Camara tied it in the 84th following a goalmouth scramble, but Giroud struck in the 87th and 89th minutes to seal the win.

___

GLASGOW, Scotland (AP) ? Gary Hooper scored a hat trick to give Celtic a 5-0 win over St. Mirren in the Scottish Premier League.

Celtic has 35 points to Rangers' 40, although the defending champions play Kilmarnock on Sunday.

Third-place Motherwell is five points further back after a 0-0 draw against Dundee United, while Aberdeen drew 3-3 at Dunfermline, Hearts beat visiting Inverness 2-1, and St. Johnstone beat Hibernian 3-1.

___

ATHENS, Greece (AP) ? Steve Leo Beleck scored a goal in each half to lead AEK Athens to a 2-0 victory at newcomer Panaitolikos in the Greek league.

The win puts AEK on top of the standings with 22 points from 11 games. Panathinaikos, which hosts OFI Sunday, is two points behind but with three games in hand.

Ergotelis beat visiting Giannena 2-1 and PAOK stumbled at home against lowly Kerkyra with a scoreless draw.

Copyright 2011 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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Source: http://nbcsports.msnbc.com/id/45447509/ns/sports-soccer/

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Sunday, 27 November 2011

Mexico's early frontrunner formalizes presidential bid (Reuters)

MEXICO CITY (Reuters) ? The frontrunner in Mexico's 2012 presidential race on Sunday pledged to break past decades of political paralysis and deliver the country from a deepening spiral of drug violence and sluggish economic growth.

Thousands of cheering supporters rallied around Enrique Pena Nieto, the charismatic young ex-governor of Mexico's most populous state, after he registered in Mexico City as the official presidential candidate of the opposition Institutional Revolutionary Party (PRI).

With a 20-point lead in national polls, Pena Nieto, 45, is the most promising candidate for the PRI since the party that ruled Mexico for most of the 20th century lost power in 2000.

After two conservative administrations and growing frustration with rising crime and economic inequality, Pena Nieto is promising Mexicans change based on the PRI's long experience in government.

"Today in Mexico there is fear, anxiety, discouragement. But at the same time there is a growing force, optimistic, and sure that better times are coming," Pena Nieto told the crowd gathered at the PRI's headquarters.

"I am part of a new generation of Mexicans who are convinced that Mexico can transform itself," Pena Nieto said, promising to make the country safer, reduce social inequality and spur growth to create jobs and opportunities for all.

PRI COMEBACK

Following its defeat in 2000, the PRI fractured. But the party's massive machine of unions, civil groups and farmers have rallied behind Pena Nieto. His good looks and message of change have captured wide support beyond the PRI's base.

"Unless the Virgin of Guadalupe intervenes, he will win the election in a landslide," said George Grayson, a professor at the College of William & Mary in Virginia.

Pena Nieto is seen by analysts and investors as Mexico's best chance to pass key economic reforms, such as opening the state oil company to private investment and reforming labor laws, due to the PRI's sway over the country's biggest unions.

While Pena Nieto's victory may seem likely, the PRI could falter in congressional races, which would hamper Pena Nieto's agenda. Rivalries between parties have scuppered major reforms ever since the PRI lost its congressional majority in 1997.

Three candidates are vying for the nomination of President Felipe Calderon's conservative National Action Party, with former education minister Josefina Vazquez Mota in the lead.

The leftist Party of the Democratic Revolution (PRD) is backing Andres Manuel Lopez Obrador, who nearly won in 2006 but is now a distant third place in the polls. [ID:nN1E7AE1A1]

Mexicans will not vote until next July, leaving plenty of time for a reversal in Pena Nieto's fortune. Calderon came from far behind to win in 2006.

NEW FACE

By the end of its 71 years of rule, the PRI was synonymous with rampant corruption that undercut Mexico's economy and allowed the country's powerful criminal gangs to flourish.

PAN candidates are trying to tar Pena Nieto's image by suggesting the PRI is still in the pockets of drug cartels.

But those charges may not stick. Pena Nieto has given the party a new face after a term as a wildly popular governor of Mexico State, where he won support by building roads and schools and steered clear of any major scandals.

"In 70 years the PRI made mistakes, got lost and tripped up, but we have been learning and we won't let it happen again," said Emilio Gamboa, who leads the PRI's popular front.

During the PAN's two administrations, the economy has grown at about a third of the pace it needs to create enough good jobs for all the young Mexicans entering the workforce.

Meanwhile, more than 45,000 people have died in Calderon's military-led offensive against drug cartels. Many backed the move to challenge the gangs, but doubts are now growing.

"People think security has gotten out of the PAN's control," said Jose Antonio Crespo from graduate school CIDE. "While they think there was corruption under the PRI, at least there was order and more effective governance."

(Additional reporting by Miguel Angel Gutierrez; editing by Anthony Boadle)

Source: http://us.rd.yahoo.com/dailynews/rss/mexico/*http%3A//news.yahoo.com/s/nm/20111127/wl_nm/us_mexico_election

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Things to give thanks for (Unqualified Offerings)

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Saturday, 26 November 2011

Mayor stages hunger strike as residents shiver (Reuters)

BUCHAREST (Reuters) ? A Romanian mayor has begun a hunger strike to protest against cuts in heating subsidies imposed under a government austerity drive, reawakening memories of the harsh final years of communism.

Mayor Florin Cazacu said 10,000 residents in the central Romanian town of Brad were braving low temperatures at home because his town hall lacked 3 million lei ($925,200) from the state budget to buy fuel oil for the winter season.

"People are suffering from cold, this is why I began this protest," Cazacu told Reuters. "I took an oath ... to do everything in my power and competence for the sake of the inhabitants."

During the last years of communist leader Nicolae Ceausescu heating was often shut down under an austerity drive aimed at repaying Romania's foreign debt.

This inflicted widespread suffering before Ceausescu's overthrow in 1989. Living standards have since risen sharply but winters remain tough for many Romanians.

The European Union's second poorest member state introduced tough austerity measures last year including salary cuts and a rise in value-added tax to one of the highest levels in the EU.

Romania has promised the International Monetary Fund, which is leading a 5 billion euro aid deal, to liberalize its gas and power markets, raise administered prices and scrap government subsidies for centralized heating.

Temperatures in winter fall as low as minus 30 Celsius degrees (-22 Fahrenheit) in the region around Brad, which has a total population of 17,000.

As apartments in Brad are not connected to mains gas, some people are using electric heaters but this has caused frequent power cuts due to town's poor electricity grid.

"I will stay on hunger strike for as long as it takes ... and give up the protest only if the government grants us the necessary funds," said 46-year-old Cazacu.

(editing by David Stamp)

Source: http://us.rd.yahoo.com/dailynews/rss/oddlyenough/*http%3A//news.yahoo.com/s/nm/20111124/od_nm/us_romania_mayor

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Friday, 25 November 2011

British police investigating climate email hackers (Reuters)

LONDON (Reuters) ? British police will examine a batch of email exchanges between climate scientists which appeared on the Internet Tuesday as part of an inquiry into the hacking of the private documents, police said Wednesday.

The University of East Anglia, whose Climate Action Research Unit is considered one of the world's leading institutions on climate science, said the emails appeared to be "a carefully-timed attempt to reignite controversy over the science behind climate change."

Negotiators from almost 200 countries meet from November 28 in South Africa for a U.N. climate summit, where only modest steps are expected toward a deal on cutting greenhouse gas emissions despite warnings from scientists that extreme weather will likely increase as the planet warms.

An anonymous group or individual called FOIA posted a file on a Russian server, http://files.sinwt.ru/download.phpfile=25FOIA2011.zip,

which included more than 5,000 emails.

Two years ago, a series of emails written by climate experts from the university were stolen by unknown hackers and spread across the Internet in what became known as "Climategate," just before a U.N. climate summit in Copenhagen.

The leaked emails contained private correspondence from 1995 to 2009. Climate change skeptics claimed they showed scientists manipulating data to support global warming.

However, independent inquiries cleared the university of all accusations of fraud and data manipulation, although they did recommend it change the way it handled requests for information.

"We are aware of the release of the document cache. The contents will be of interest to our investigation which is ongoing," said police spokeswoman Nicola Atter.

"Nothing so far leads us to believe the emails raise any new issues. If, on closer study, we see anything that requires further investigation, that we will do," Edward Acton, vice chancellor of the university, told reporters Wednesday.

"It may throw more light on the perpetrator rather than the victims of this invasion of privacy. I am very keen to know who did it," he added.

Police would not reveal information about suspects but said it was following "all lines of enquiry, some of which have been international in nature."

Acton said the way numbers appeared, using full stops instead of commas, was uncommon among British or American English speakers.

In addition to the 5,000 emails released Tuesday, there are another 39,000 pages which cannot be accessed yet as they require a password, the vice-chancellor said.

Those seen so far include quotes on discussions between scientists over how to portray climate data, the workings of the U.N.'s Intergovernmental Panel on Climate Change and how to share information.

"I have looked at 100 or so and those highlighted are quite cherry-picked (...) They are quite representative of frank and honest discussion between scientists," said Phil Jones, head of the university unit.

In a statement immediately after the emails appeared on the Internet Tuesday, the university said: "This appears to be a carefully-timed attempt to reignite controversy over the science behind climate change when that science has been vindicated by three separate independent inquiries and a number of studies."

(Reporting by Nina Chestney; Editing by Janet Lawrence)

Source: http://us.rd.yahoo.com/dailynews/rss/tech/*http%3A//news.yahoo.com/s/nm/20111123/wr_nm/us_climate_emails

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Could iTunes Be Used To Spy On You?

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Could iTunes Be Used To Spy On You?
British firm Gamma International was found hawking spyware to foreign intelligence services that installed onto users' computers via an iTunes security hole. The breach has been fixed, but documents indicate that the exploit was used to snoop on the email, Skype, and social media activities of users worldwide.

Source: FastCompany
Posted on: Wednesday, Nov 23, 2011, 10:02am
Views: 14

Source: http://www.labspaces.net/115442/Could_iTunes_Be_Used_To_Spy_On_You_

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Thursday, 24 November 2011

CrunchBase Reveals: Figuring Out Pricing Formulas For Talent Acquisitions With Opani

Screen Shot 2011-11-22 at 2.22.02 PMFollowing my post last night about our effort to use CrunchBase in more ways on TechCrunch, some readers have shared how they're already using it. One was Dirk Neumann from "social supercomputer" startup Opani, which provides tools to help people more easily analyze large data sets. He's used CrunchBase data to try to come up with a formula for pricing talent in startup acquisitions. His analysis, below, is in response to a recent panel at law firm Orrick, where a number of acquisition heads at major tech companies had noted that there was "no general formula" for doing so. He identified 71 early-stage acquisitions and 84 late-stage acquisitions in CrunchBase, then further defined the early stage group as startups purchased for below $66 million, with fewer than 50 employees, and investments of less than $5 million. Later-stage companies were defined as having acquisition prices above $66 million and between 50 and 500 employees. The findings are a bit rough, but here they are:

Source: http://feedproxy.google.com/~r/Techcrunch/~3/eA8U3fxIbH0/

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Wednesday, 23 November 2011

Universal Motion Simulator: real enough to evoke panic (video)

A fighter sim just isn't realistic unless it makes you throw up and scream for your mother, which is why the sadistic folks at Australia's Deakin University created the Universal Motion Simulator. It's a barebones cockpit attached to the end of a seven-meter robotic arm that can pull up to six Gs -- indeed it's uncomfortable enough to mimic external disturbances, mechanical failures and crash scenarios as well as normal flying. The system also monitors a pilot's brainwaves, pulse and other bodily functions to discover if they have necessary nerve. Check out the video after the break and then imagine combining it with a 360-degree viewing dome for utter perfection.

Continue reading Universal Motion Simulator: real enough to evoke panic (video)

Universal Motion Simulator: real enough to evoke panic (video) originally appeared on Engadget on Mon, 21 Nov 2011 19:37:00 EDT. Please see our terms for use of feeds.

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Quotes from Republican presidential debate (Reuters)

(Reuters) ? The Republican presidential contenders met on Tuesday for their 11th debate in the race for the nomination to challenge President Barack Obama in 2012.

The debate centered on national security and foreign policy. Here are some of their quotes:

MITT ROMNEY, FORMER MASSACHUSETTS GOVERNOR

On U.S. aid to Pakistan

"We need to bring Pakistan into the 21st century, or the 20th century for that matter."

How to prevent a nuclear Iran:

"The right course in America is to stand up to Iran with crippling sanctions, indict Ahmadinejad for violating the Geneva -- or the Genocide Convention...I know it's going to make gasoline more expensive. There's no price which is worth an Iranian nuclear weapon."

RICK SANTORUM, FORMER U.S. SENATOR FROM PENNSYLVANIA

On profiling Muslims:

"Well, the folks who are most likely to be committing these crimes. If you look at -- I mean, obviously, it was -- obviously, Muslims would be, would be someone you'd look at, absolutely. Those are the folks who are, the radical Muslims are the people that are committing these crimes."

NEWT GINGRICH, FORMER HOUSE OF REPRESENTATIVES SPEAKER

Whether cuts to defense spending are unacceptable:

"No...it's clear that there are some things you can do in defense that are less expensive. It's clear, if it takes 15 to 20 years to build a weapons system at a time when Apple changes technology every nine months, there's something profoundly wrong with this system. So I'm not going to tell you automatically I'm going to say yes."

On amnesty for illegal immigrants:

"I don't see how the party that says it's the party of the family is going to adopt an immigration policy which destroys families that have been here a quarter century. And I'm prepared to take the heat for saying, let's be humane in enforcing the law without giving them citizenship but by finding a way to create legality so that they are not separated from their families."

On the killing of Osama bin Laden:

"We were told, a perfectly natural Washington assumption, that our killing bin Laden in Pakistan drove U.S.-Pakistan relations to a new low. To which my answer is, well, it should have because we should be furious."

Supporting the Patriot Act:

"No, I would not change it ... And I'd look at strengthening it, because I think the dangers are literally that great."

HERMAN CAIN, FORMER PIZZA EXECUTIVE

On the need to keep the Patriot Act:

"The terrorists have one objective that some people don't seem to get. They want to kill all of us. So we should use every mean possible to kill them first or identify them first."

Mixing up CNN moderator Wolf Blitzer's name:

"No, Blitz ... I'm sorry, Blitz, I meant Wolf, OK? This was --since we're on a, since we're on a blitz debate. I apologize."

RICK PERRY, TEXAS GOVERNOR

How to stop an Iranian nuclear program:

"We need to sanction the Iranian central bank. That would be one of the most powerful ways to impact that... What we need to do before we ever start having any conversations about a military strike, is to use every sanction that we have."

Proposing a no-fly zone over Syria:

"If we're serious about Iran, and that's what we're really talking about. Syria is a partner with Iran in exporting terrorism all across that part of the world and around the globe. So if we're serious abut Iran then we have to be serious about Syria as well."

Criticizing U.S. aid to Pakistan:

"To write a check to countries that are clearly not representing American interests is nonsensical."

On congressional failure to agree on budget cuts:

"I don't think anybody is particularly surprised that the super committee failed. It was a super failure. And I think we expected that."

MICHELE BACHMANN, U.S. CONGRESSWOMAN FROM MINNESOTA

On Pakistan:

"Pakistan is a nation, that it's kind of like too nuclear to fail."

RON PAUL

On aid to impoverished countries:

"I think the aid is all worthless. It doesn't do any good for most of the people. You take money from poor people in this country and you end up giving it to rich people in poor countries."

On border security and immigration:

"The drug war was mentioned. I think that's another war we ought to cancel."

(Compiled by Lily Kuo)

Source: http://us.rd.yahoo.com/dailynews/rss/obama/*http%3A//news.yahoo.com/s/nm/20111123/ts_nm/us_usa_campaign_debate_quotes

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Tuesday, 22 November 2011

Secretive North Korea opens up to cellphones (Reuters)

SEOUL (Reuters) ? Secretive North Korea is expected to register the 1 millionth cellphone user on its new 3G network by the end of the year, barely four years after people were thrown into prison camps, or possibly even executed, for owning one.

Most of the users are in the capital of Pyongyang, home to the impoverished country's elite and powerful who have the cash to splash out for a device and the calling fees.

"There has been an astronomical increase since even two years ago," said Michael Hay, a lawyer and business consultant based in the capital for the past seven years.

Two years ago, there were fewer than 70,000 users.

"All the waitresses in coffee shops have them, as one example, and use them. Let's not even talk about businessmen. The are never off them, and conversations are frequently interrupted by mobile calls."

The authoritarian government ended a ban on cellphones in 2008, signing a four-year deal with Egyptian company Orascom to build the 3G network in partnership with the government.

A report this month by the Nautilus Institute for Security and Sustainability said 60 percent of people ages 20 to 50 use cellphones in Pyongyang, a city of around 3 million people who are strictly vetted by the state for residency permits.

"Especially for the younger generation in their 20s and 30s, as well as the merchant community, a cellphone is seen as a must, and many youngsters can no longer see their lives without it," Alexandre Mansourov wrote in the report.

Calling fees have fallen this year, driving the surge in demand, reports say. And the introduction of the "Euro pack" bundle provides the isolated government with some much-needed hard foreign currency.

But you can't dial into or out of the country, and there's no Internet. The government still keeps a stranglehold on all news flows into the destitute state.

While the 3G network covers 94 percent of the population, it still only covers 14 percent of the territory, according to Orascom, involved in a joint venture with the government.

North Koreans who have defected to the South say the cost of buying a cellphone and the operating fees, mean owning such a 3G device is out of question for most. Phones cost about $350 in the country where the average monthly income is about $15.

"The possession of cellphones was not limited by class, but not many people have cellphones because they are just too expensive," said Kim Seong-hu, 40, who defected to South in April. "Most commoners are satisfied with landlines we have."

Cheap illegal cellphones tapping into Chinese networks are not uncommon, but their range is limited to just the border fringe.

NO THREAT, YET

Analysts say the 3G network does not pose a threat to the government in the way cellphones have fueled uprisings around the Arab world this year.

Cellphones and the Internet have been used to rally a revolutionary wave of protests and civil wars that have brought down iron rulers from Hosni Mubarak to Muammar Gaddafi.

But analysts say this is unlikely to happen in North Korea because strict state media controls limit what the poor know about the outside world and there is no immediate sense of revolt.

"In the long run, the growth of interaction between people is a problem for the regime, but it might take years, or even decades, before the situation will be ripe for an outbreak of internal discontent," said Andrei Lankov of Kookmin University in Seoul.

The North banned the use of cellphones in 2004 after an explosion at the Ryongchon railway just a few hours after train carrying leader Kim Jong-il passed through it. Security officials suspect a cellphone was used to ignite the bomb.

Pyongyang's lifting of the ban paved the way for Orascom's entry into the market. It threw some $400 million into developing the North's first and only 3G network.

Last week, Orascom reported there were more than 800,000 users on its network, compared with 300,000 at the same time last year.

Despite its obsession with secrecy and control, North Korea's authoritarian leadership is opening up its telecommunication services and encouraging IT development.

Ironically, its isolationist policy of Juche has made its drive to catch up a lot easier than for other countries that have traveled the path of IT development.

"As a laggard in the global digital revolution, Pyongyang enjoys key advantages of backwardness -- dramatic savings on initial R&D costs in the IT sector, the opportunity to leap frog from exclusive reliance on obsolete and scarce landlines to world class 3G mobile communications," says Mansourov.

"The DPRK (North Korea) mobile communications industry has crossed the Rubicon and the North Korean government can no longer roll it back without paying a severe political price."

(Additional reporting by Iktae Park)

Source: http://us.rd.yahoo.com/dailynews/rss/tech/*http%3A//news.yahoo.com/s/nm/20111120/tc_nm/us_korea_north_cellphone

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Monday, 21 November 2011

Tweaking a gene makes muscles twice as strong: New avenue for treating muscle degeneration in people who can't exercise

ScienceDaily (Nov. 21, 2011) ? An international team of scientists has created super-strong, high-endurance mice and worms by suppressing a natural muscle-growth inhibitor, suggesting treatments for age-related or genetics-related muscle degeneration are within reach.

The project was a collaboration between researchers at the Salk Institute for Biological Studies, and two Swiss institutions, Ecole Polytechnique Federale de Lausanne (EPFL) and the University of Lausanne.

The scientists found that a tiny inhibitor may be responsible for determining the strength of our muscles. By acting on a genome regulator (NCoR1), they were able to modulate the activity of certain genes, creating a strain of mighty mice whose muscles were twice a strong as those of normal mice.

"There are now ways to develop drugs for people who are unable to exercise due to obesity or other health complications, such as diabetes, immobility and frailty," says Ronald M. Evans, a professor in Salk's Gene Expression Lab, who led the Salk team. "We can now engineer specific gene networks in muscle to give the benefits of exercise to sedentary mice."

Johan Auwerx, the lead author from EPFL, says molecules such as NCoR1 are molecular brakes that decrease the activity of genes. Releasing the brake by mutation or with chemicals can reactivate gene circuits to provide more energy to muscle and enhance its activity.

In an article appearing in the journal Cell, the Salk researchers and their collaborators reported on the results of experiments done in parallel on mice and nematodes. By genetically manipulating the offspring of these species, the researchers were able to suppress NCoR1, which normally acts to inhibit the buildup of muscle tissues.

In the absence of the inhibitor, the muscle tissue developed much more effectively. The mice with the mutation became true marathoners, capable of running faster and longer before showing any signs of fatigue. In fact, they were able to cover almost twice the distance run by mice that hadn't received the treatment. They also exhibited better cold tolerance.

Unlike previous experiments that focused on "genetic accelerators" this work shows that suppressing an inhibitor is a new way to build muscle. Examination under a microscope confirmed that the muscle fibers of the modified mice are denser, the muscles are more massive, and the cells in the tissue contain higher numbers of mitochondria -- cellular organelles that deliver energy to the muscles.

Similar results were also observed in nematode worms, allowing the scientists to conclude that their results could be applicable to a large range of living creatures.

The scientists have not yet detected any harmful side effects associated with eliminating the NCoR1 receptor from muscle and fat tissues. Although the experiments involved genetic manipulations, the researchers are already investigating potential drug molecules that could be used to reduce the receptor's effectiveness.

The researchers say their results are a milestone in our understanding of certain fundamental mechanisms of living organisms, in particular the little-studied role of corepressors -- molecules that inhibit the expression of genes. In addition, they give a glimpse at possible long-term therapeutic applications.

"This could be used to combat muscle weakness in the elderly, which leads to falls and contributes to hospitalizations," Auwerx says. "In addition, we think that this could be used as a basis for developing a treatment for genetic muscular dystrophy."

He added that if these results are confirmed in humans, there's no question they will attract interest from athletes as well as medical experts.

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Story Source:

The above story is reprinted from materials provided by Salk Institute.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Hiroyasu Yamamoto, Evan?G. Williams, Laurent Mouchiroud, Carles Cant?, Weiwei Fan, Michael Downes, Christophe H?ligon, Grant?D. Barish, B?atrice Desvergne, Ronald?M. Evans, Kristina Schoonjans, Johan Auwerx. NCoR1 Is a Conserved Physiological Modulator of Muscle Mass and Oxidative Function. Cell, 2011; 147 (4): 827 DOI: 10.1016/j.cell.2011.10.017

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://www.sciencedaily.com/releases/2011/11/111121104509.htm

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Ziad Bahaa-Eldin on the "legal chaos" of the elections - Blog - The ...

[unable to retrieve full-text content]For this week's translation -- courtesy our friends at Industry Arabic, as usual -- we have selected a column by legal expert, economic and political analyst and parliamentary candidate Ziad Bahaa-Eldin that appeared in the ...

Source: http://www.arabist.net/blog/2011/11/20/ziad-bahaa-eldin-on-the-legal-chaos-of-the-elections.html

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Sunday, 20 November 2011

HTC Rezound (Verizon Wireless)

[unable to retrieve full-text content]The HTC Rezound is an amazing Internet and multimedia machine that fits into your pocket, but it's bulky and a little buggy.


Source: http://feedproxy.google.com/~r/ziffdavis/pcmag/~3/cM20fRSraPc/0,2817,2396392,00.asp

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Syrian troops attack despite Arab peace plan

Syrian troops stormed a central town and a northwestern region in search of regime opponents on Saturday, activists said, a day after the government agreed in principle to allow the Arab League to send observers to oversee a peace plan proposed by the 22-member bloc.

The attacks on the town of Shezar in the central province of Hama and on the restive Jabal al-Zawiya region near the Turkish border came as pressure mounted on Damascus to end its eight-month crackdown on anti-government protesters. The unrest has killed more than 3,500 people since mid-March, according to U.N. estimates.

The British-based Syrian Observatory for Human Rights and another activist group called the Local Coordination Committees said land and cellular telephone lines as well as electricity were cut in the Jabal al-Zawiya region, where army defectors have been active for months.

Elsewhere, two army defectors were killed in a clash with troops in Qusair near the border with Lebanon, while a civilian was killed by security forces in Hama, said the observatory. The Local Coordination Committees had a different toll, saying one person was killed in Qusair and one in the central city of Homs.

Syria agreed in principle Friday to allow dozens of Arab observers into the country to oversee an Arab League peace plan that calls on the government to stop attacking demonstrators, pull tanks out of cities and begin negotiations with the opposition.

It was a significant concession from a hard-line regime that loathes any sort of outside interference. But critics say the government is only stalling, trying to defuse international pressure while continuing its bloody crackdown.

The Arab League has already suspended Syria's membership in the bloc for failing to abide by the peace plan. On Wednesday, the league gave Damascus three days to accept the observer mission or face economic sanctions.

Violence has escalated in Syria over the past week, as army dissidents who sided with the protests have grown more bold, fighting back against regime forces and even assaulting military bases. Activist groups said security forces on Friday killed at least 16 anti-government protesters.

Pressure from European capitals and the U.S. is also building on President Bashar Assad to end the bloodshed.

An official at Britain's Foreign Office said Foreign Secretary William Hague intends to meet opposition representatives in London on Monday.

French Foreign Minister Alain Juppe called on the U.N. Security Council to strengthen sanctions against Assad's regime. However, Russia, which holds veto power in the council, urged caution in moving against Damascus.

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In Washington, State Department spokesman Mark Toner said the U.S. has seen no signs that Syria's government will honor the Arab League proposal.

Syria's neighbor to the north, Turkey, has become one its most vocal critics, a notable shift because the two countries once had close political and economic ties.

On Saturday, Turkish Prime Minister Recep Tayyip Erdogan, commenting on the deteriorating relations between his country and its southern neighbor, accused Syria of not fulfilling promises for reform or to stop the bloodshed.

"In the past nine years, it was Syria and the Syrian people ? rather than Turkey ? that had benefited from the Turkish-Syrian friendship," Erdogan said.

"... Syria has not kept its promises to Turkey, to the Arab League or to the world. It made promises but did not fulfill them. It has not acted in a sincere trustworthy manner," he said.

The attacks on Jabal al-Zawiya came two days after an army force in the nearby area of Wadi al-Deif came under attack by army defectors, a clash that lasted four hours and left an unknown number of casualties among troops loyal to Assad, an activist said.

The activist, who spoke on condition of anonymity because of the sensitivity of the matter, said troops fired heavy machine guns mounted on armored personnel carriers.

The Arab League observer mission aims to prevent violence and monitor a cease-fire that Damascus agreed to last week but has been unwilling ? or unable ? to implement.

Nabil Elaraby, the head of the Arab League, said in a statement Friday that he received "amendments" to the monitoring mission from Damascus, which the league is studying. He gave no details on the changes Syria seeks.

The original league proposal had been for a 500-member observer mission but the number has dropped to 40, said Ibrahim el-Zaafarani, an Egyptian member of the Arab Medical Union who is expected to be part of the team for Syria. He said it was not clear why or on whose behest the number was reduced.

___

Associated Press writers Suzan Fraser in Ankara, Turkey, and Meera Selva in London contributed to this report.

___

Bassem Mroue can be reached on http://twitter.com/bmroue

Copyright 2011 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://www.msnbc.msn.com/id/45366014/ns/world_news-mideast_n_africa/

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Saturday, 19 November 2011

Afghan heroin traffic thrives in war: Russia (Reuters)

CHICAGO (Reuters) ? U.S. efforts to eradicate Afghanistan's opium poppy crops, which cover an area about the size of New York City, have been "unsatisfactory," Russia's anti-drug czar said Thursday.

Russia is the world's largest per capita consumer of heroin and is coping with an epidemic of HIV/AIDS spread by dirty needles.

Afghanistan has long been the world's leading producer of opium, used to make heroin, and one-quarter of its production traverses its porous border with former Soviet states and supplies as many as 3 million Russian addicts.

Viktor Ivanov, director of Russia's Federal Service for the Control of Narcotics, in Chicago for meetings with his American counterparts, said he agreed with the dim assessment of U.S. poppy eradication efforts by some members of the U.S. Congress.

"Their words were that the efforts are unsatisfactory," Ivanov said through an interpreter in an interview with Reuters. He referred to Democratic Senator Dianne Feinstein and Republican Senator Charles Grassley, who co-chair a caucus on international drug trafficking.

Russia has said the United States made a mistake in 2009 by phasing out crop eradication efforts to focus instead on intercepting drugs and hunting production labs and drug lords.

President Barack Obama has committed to turning over security to Afghan control by the end of 2014. The United States launched the war weeks after the September 11, 2001, attacks, targeting al Qaeda and the Taliban.

Joint Russian-American anti-drug operations have appeared to tail off since a raid in October 2010 seized a ton of heroin and destroyed four drug-producing laboratories.

There were four more joint raids conducted between December 2010 and February 2011, but Ivanov said it was cumbersome to obtain military approval quickly, given time-sensitive intelligence.

IDEOLOGICALLY NEUTRAL

In spite of concerns that the Taliban and other insurgent elements were financed by illegal drug profits, Ivanov said absentee landowners and traffickers who reap the bulk of the $7 billion in illegal drug proceeds did not have an ideological stake in the decade-old war. The Taliban earned $150 million annually from drug trafficking, he said.

But the traffickers have hijacked the military's transportation infrastructure in Afghanistan to help them ship their product, he said.

The rising number of violent clashes in Afghanistan worked against any effort to persuade farmers to grow legal crops instead of opium poppies, Ivanov said.

"Ask any farmer if he's growing wheat and at the same time his country is torn by all sorts of military clashes. How safe will he feel about the future of his crops and the eventual sale of his crops?" Ivanov said.

"That's why we think the most efficient and effective measure is to destroy the product, the drug plantations and the drug laboratories," he said.

The United Nations said land devoted to opium poppy cultivation in Afghanistan rose 7 percent this year to 1,310 square kilometers (506 sq miles), much of it in the less-secure south and east.

"This tremendous amount of heroin is produced on a relatively small territory ... about the area of New York City," Ivanov said.

He lobbied for creation of a digital poppy map that would identify poppy plantations and show where eradication was working, or not. The publicly accessible map would use surveillance data gathered by American drones and possibly a Russian-American satellite dedicated to the task.

Ivanov said Russia, which fought its own costly war in Afghanistan in the 1980s, had also embarked on a concerted effort to treat its own addicts, which critics say it has often failed to do up to now.

Scientists were working on a new pharmaceutical approach that would suppress the urge to use while not substituting one drug for another. Russian officials have rejected methadone, saying it is merely exchanges one addiction for another.

U.S. addiction rates were also on the rise, Ivanov warned, with many users smoking or inhaling purer Afghan heroin.

(Editing by Eric Beech)

Source: http://us.rd.yahoo.com/dailynews/rss/world/*http%3A//news.yahoo.com/s/nm/20111117/wl_nm/us_usa_russia_afghanistan_heroin

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Friday, 18 November 2011

Does your car get 54.5 miles a gallon? That's what EPA wants for 2025. (Christian Science Monitor)

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Patriots relying on newcomers in secondary (AP)

FOXBOROUGH, Mass. ? New England's defensive backs are trying to prepare for a quarterback they've hardly seen.

The same can be said of Kansas City's Tyler Palko getting ready for the Patriots' secondary, which has been spread thin by recent injuries.

"Whenever you're number is called, you just have to adapt. See your role and just be ready," said cornerback Kyle Arrington, one of New England's few defensive backs who hasn't been knocked out of the lineup this season. "You always have to prepare like you're going to be out there."

Sterling Moore is coming off his first career start and preparing for may be his second in a row. A cornerback the Patriots picked up after he was released by Oakland, stepped in at safety as Patrick Chung was out with a foot injury.

Antwaun Molden, who was claimed off waivers in September, had to take over at corner when starter Devin McCourty injured his right his shoulder during the first half of a win over the Jets.

If Chung and McCourty are still out Monday, the Patriots will have to rely once again on some of their newest players when they host the Chiefs on Monday night.

"It's a great opportunity for us to continue the success that we had in the secondary last week," Moore said before practice Thursday.

The Patriots will be going up against Palko, who is making his first career start and has played in only two games this season. There isn't a lot of video to review on Palko, who replaced former Patriots quarterback Matt Cassel.

The patched-up secondary helped keep New York's Mark Sanchez in check as the Patriots won 37-16. Sanchez passed for 306 yards, but completed only 20 of 39 passes and was intercepted twice by linebacker Rob Ninkovich.

Backup safety Josh Barrett was placed on injured reserve last week, opening a spot on the active roster for Moore, an undrafted free agent who went through training camp with the Raiders but was a late cut.

"It was kind of hectic last week, especially earlier in the week knowing that I might have a chance to get out there. A lot more playbook study and a lot more film watching. It's nothing that I'm not too used to," Moore said. "I'm definitely getting a lot more comfortable with the guys that I'm back there with. I know we've got a lot of interchanging parts but we're pretty comfortable with who we've got back there."

The Patriots have also been using cornerback Phillip Adams the last few weeks. He has been off and on the active roster since the Patriots picked him up in September after he was released by San Francisco.

New England started another undrafted rookie at linebacker last week when Jeff Tarpinian stepped in for Brandon Spikes. Tarpinian was actually more experienced than some of his newer teammates, subbing in six games before getting the start.

Even with all the new faces, the New England defense had one of its best games of the season. It wasn't enough to bump the Patriots from last place on the NFL total defense standings, but the Patriots played well enough to win and take control of the AFC East.

Andre Carter, another newcomer to New England, set a franchise record with 4 1-2 sacks and was named AFC defensive player of the week. The Patriots picked up the veteran as a free agent in August.

"All these guys, I'm talking offense, defense, special teams ? this team ? works very, very hard. When you have a guy go out and put up a performance like Andre did, you can't be nothing but happy for him," nose tackle Vince Wilfork said. "To be good you have to be able to make adjustments at times. We've handled it well so far and hopefully we can continue to get better."

Source: http://us.rd.yahoo.com/dailynews/rss/sports/*http%3A//news.yahoo.com/s/ap/20111117/ap_on_sp_fo_ne/fbn_patriots_secondary

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Thursday, 17 November 2011

Tucson Survivors Back Gun Control (ABC News)

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Supreme Court: Pre-election health care showdown

FILE - In this Jan. 7, 2008 file photo, attorney Donald Verrilli, who argued against the use of a three drug cocktail used to execute inmates, gestures as he talks to media outside the Supreme Court in Washington, after arguments about the lethal injection death penalty. The Supreme Court on Monday, Nov. 14, 2011, promised an extraordinarily thorough springtime review of President Barack Obama's historic health care overhaul _ more than five hours of argument, unprecedented in modern times _ in time for a likely ruling affecting millions of Americans just before the presidential election. Verrilli, the current solicitor general, is expected to defend the law before the justices. (AP Photo/Evan Vucci, File)

FILE - In this Jan. 7, 2008 file photo, attorney Donald Verrilli, who argued against the use of a three drug cocktail used to execute inmates, gestures as he talks to media outside the Supreme Court in Washington, after arguments about the lethal injection death penalty. The Supreme Court on Monday, Nov. 14, 2011, promised an extraordinarily thorough springtime review of President Barack Obama's historic health care overhaul _ more than five hours of argument, unprecedented in modern times _ in time for a likely ruling affecting millions of Americans just before the presidential election. Verrilli, the current solicitor general, is expected to defend the law before the justices. (AP Photo/Evan Vucci, File)

FILE - In this June 3, 2011 file photo, Paul Clement, a lawyer representing the NFL, arrives at the federal courthouse in St. Louis. The Supreme Court on Monday, Nov. 14, 2011, promised an extraordinarily thorough springtime review of President Barack Obama's historic health care overhaul _ more than five hours of argument, unprecedented in modern times _ in time for a likely ruling affecting millions of Americans just before the presidential election. Clement, former Bush administration solicitor general, is likely to argue on behalf of the challengers. (AP Photo/Jeff Roberson, File)

FILE - In this March 23, 2010 file photo President Barack Obama signs the health care bill in the East Room of the White House in Washington. He is flanked by Marcelas Owens of Seattle, left, and Rep. John Dingell, D-Mich. Behind, from left are, Sen. Tom Harkin, D-Iowa., Senate Majority Whip Richard Durbin of Ill., Vice President Joe Biden, Vicki Kennedy, widow of Sen. Ted Kennedy, Sen. Christopher Dodd, D-Conn., Rep. Sander Levin, D-Mich., Ryan Smith of Turlock, Calif., Health and Human Services Secretary Kathleen Sebelius, House Speaker Nancy Pelosi of Calif., House Majority Leader Steny Hoyer of Md., Senate Majority Leader Harry Reid of Nev., Rep. Patrick Kennedy, D-R.I., House Majority Whip James Clyburn of S.C., and Rep. Henry Waxman, D-Calif. The Supreme Court said Monday it will hear arguments in March over President Barack Obama?s health care overhaul, setting up an election-year showdown over the White House's main domestic policy achievement. (AP Photo/J. Scott Applewhite, File)

FILE - In this May 3, 2011 file photo, the Supreme Court is seen in Washington. The Supreme Court said Monday it will hear arguments in March over President Barack Obama?s health care overhaul, setting up an election-year showdown over the White House's main domestic policy achievement. (AP Photo/Alex Brandon, File)

FILE - In this Nov. 8, 2011 file photo, Senate Minority Leader Mitch McConnell of Ky. speaks on Capitol Hill in Washington. The Supreme Court said Monday it will hear arguments in March over President Barack Obama?s health care overhaul, setting up an election-year showdown over the White House's main domestic policy achievement. (AP Photo/J. Scott Applewhite, File)

(AP) ? The Supreme Court on Monday promised an extraordinarily thorough springtime review of President Barack Obama's historic health care overhaul ? more than five hours of argument, unprecedented in modern times ? in time for a likely ruling affecting millions of Americans just before the presidential election.

That ruling, expected before next summer's Independence Day holiday, could determine the fate of Obama's signature domestic achievement, the most far reaching domestic legislation in a generation but a political lightning rod as well. It is vigorously opposed by all of Obama's prospective GOP opponents.

The Patient Protection and Affordable Care Act aims to provide health insurance to more than 30 million previously uninsured Americans. But Republicans have branded the law unconstitutional since before Obama signed it in a ceremony in March 2010.

The court's ruling could be its most significant and political decision since George W. Bush's 2000 presidential election victory. But the justices left themselves an opening to defer the outcome if they choose, by requesting arguments on one lower court's ruling that a decision must wait until 2015, when one of the law's many provisions takes effect.

Legal experts have offered a range of opinions about what the high court might do. Many prominent Supreme Court lawyers believe the law will be upheld by a lopsided vote, with Republican and Democratic appointees ruling in its favor. But others predict a close outcome, with Justice Anthony Kennedy, a Republican appointee who sometimes joins his four colleagues appointed by Democratic presidents, holding the deciding vote on the nine-member court.

The White House has pushed for a final ruling as soon as possible, and Communications Director Dan Pfeiffer said the administration was pleased the justices agreed to take the case now, with arguments in March. "It's important that we put to rest once and for all the issue of maybe the law will disappear," said Health and Human Services Secretary Kathleen Sebelius.

Republicans also said they were happy the high court would hear arguments on the constitutionality of the provision at the heart of the law and three other questions about the act. The central provision in question is the requirement that individuals buy health insurance starting in 2014 or pay a penalty.

"That the Supreme Court is taking this up, I think, is a positive signal that there are legitimate concerns surrounding the constitutional aspects of mandating that individuals purchase health care insurance and purchase it according to Washington's guidelines," said House Majority Leader Eric Cantor of Virginia.

The exceptional five and a half hours allotted for argument demonstrates the significance the justices see in this case. Normally, they allow only one hour, split between two sides. In the modern era, the last time the court increased that time anywhere near this much was in 2003 for consideration of the McCain-Feingold campaign finance overhaul. That case consumed four hours of argument.

This argument may even spread over two days, as the justices rarely hear more than two or three hours a day.

The health care overhaul would achieve its huge expansion of coverage by requiring individuals to buy health insurance starting in 2014, by expanding Medicaid and by applying other provisions, many yet to take effect.

The central question before the court is whether the government has the power to force people to buy health insurance. The White House says Congress used a "quintessential" power ? its constitutional ability to regulate interstate commerce, including the health care industry ? when it passed the overhaul.

But opponents of the law, and the 11th U.S. Circuit Court of Appeals in Atlanta, say that Congress overstepped its authority when lawmakers passed individual mandate. A divided Atlanta court panel ruled that Congress cannot require people to "enter into contracts with private insurance companies for the purchase of an expensive product from the time they are born until the time they die."

The Atlanta court is the only one of four appellate courts that found the mandate unconstitutional. The federal appeals court in Cincinnati upheld the entire law, as did appellate judges in Washington, D.C., in recent days. The appellate court in Richmond, Va., ruled a judicial decision on the law cannot be rendered until 2015, after the penalties for not having insurance have gone into effect.

Supporters have been encouraged that the appellate rulings in Cincinnati and Washington to uphold the law were joined by two prominent conservative judges appointed by Republican presidents: Jeffrey Sutton, appointed by George W. Bush, and Laurence Silberman, appointed by Ronald Reagan.

In Atlanta, however, Frank Hull, appointed by President Bill Clinton, joined with a Republican colleague in striking down the mandate.

Earlier District Court rulings followed political affiliation: Judges appointed by Democratic presidents upheld the law, while Republican appointees struck it down.

In addition to deciding the constitutionality of the central mandate, the justices also will determine whether the rest of the law can take effect even if that core is held unconstitutional. The law's opponents say the whole thing should fall if the individual mandate falls.

The administration counters that most of the law still could function, but says that requirements that insurers cover anyone and not set higher rates for people with pre-existing conditions are inextricably linked with the mandate and shouldn't remain in place without it.

The court also will look at the expansion of the joint federal-state Medicaid program that provides health care to poorer Americans, even though no lower court called that provision into question. Florida and 25 other states argued unsuccessfully in lower courts that the law goes too far in coercing them to participate by threatening a cutoff of federal money. The states contend that the vast Medicaid expansion and the requirement that employers offer health insurance violate the Constitution.

"The court recognized the seriousness of these vitally important constitutional challenges by allocating an extraordinary amount of time for oral argument," Florida Attorney General Pam Bondi said.

Lastly, the justices will consider whether arguments are premature because a federal law generally prohibits challenges to taxes until the taxes are paid. The federal appeals court in Richmond year reasoned that the penalty for not purchasing insurance will not be paid before federal income tax returns are due in April 2015, therefore it is too early for a court ruling.

The administration sought prompt Supreme Court review and shunned the available options for trying to delay the court's consideration until after the election. The Justice Department passed up the chance to ask the appeals court in Atlanta to reconsider its decision, though it is common to seek review by the full appeals court when a three-judge panel rules against the government.

Six separate appeals were filed with the high court. Three came from the Atlanta court, where the administration, the states and the National Federation of Independent Business appealed different aspects. From Richmond, Liberty University and Virginia appealed court decisions turning back their challenges. The Thomas More Law Center of Ann Arbor, Mich., appealed a ruling by the Cincinnati-based court upholding the law.

Ultimately, the court chose the Atlanta court's ruling as the primary case to review. That decision means that a highly regarded former Bush administration solicitor general, Paul Clement, is likely to argue on behalf of the challengers. The current solicitor general, Donald Verrilli Jr., is expected to defend the law before the justices.

Two justices, conservative Clarence Thomas and liberal Elena Kagan, who had been asked by advocacy groups to withdraw from the case, are going to take part in it. The court's practice is for justices who are staying out of a case to say so when it is accepted, and no one has announced a recusal. Thomas's wife, Virginia, has worked for a group that has advocated against the health care overhaul, and Kagan served as solicitor general in the Obama administration when the law was being formulated.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2011-11-14-US-Supreme-Court-Health-Care/id-cb4481f5a199482092751b1affd6e0b5

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Wednesday, 16 November 2011

Boxee's New Live TV Dongle Gives You Another Reason to Ditch Cable [Streaming]

Boxee just announced a new dongle that'll let Boxee users watch Live TV on their Boxee Box. Sounds cool! Well, sort of. Boxee's Live TV only supports local networks and costs 50 bucks but it will route everything you watch through Boxee's sweet interface. More »


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