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LOS ANGELES - The Roman Catholic Archdiocese of Los Angeles will soon reveal 30,000 pages of confidential personnel files without blacking out the names of the church leaders who knew about sexual abuse by priests and made key decisions on how to handle it, an archdiocese attorney said Wednesday.
The names of any bishops, vicars for clergy and supervisory parish priests will be included in all the documents and they will be turned over to lawyers for abuse victims soon, said archdiocese attorney Michael Hennigan. Vicars for clergy are responsible for priestly discipline and often made significant decisions about how to handle problem priests with input from the bishop or archbishop.
"We have chosen to remove redactions of those key individuals on every document," Hennigan said in an email. "There will be no ambiguity."
The commitment to release the documents without significant redactions comes after a five-year legal battle over the priests' privacy rights and a more recent dispute in court with The Associated Press and the Los Angeles Times, along with victims, over identifying those in positions of responsibility within the archdiocese.
A first round of 14 priest files made public in Los Angeles nearly two weeks ago showed that recently retired Cardinal Roger Mahony and other top officials maneuvered behind the scenes to shield molester priests, provide damage control for the church and keep parishioners in the dark about sexual abuse in their parishes. Those documents, released as part of an unrelated civil lawsuit, were not redacted and provided a glimpse of what could be contained in the larger release expected no later than Feb. 22.
Rochelle Wilcox, the attorney representing the AP and the Los Angeles Times, said the church's promise was a victory for the public's right to know how church leaders handled molesting priests.
The media organizations filed an objection Wednesday to a proposed order by the archdiocese that would have allowed it to release the files with the names blacked out, but with a cover sheet on the top of each priest's file listing the names of top church leaders who handled the case.
Hennigan, in an email Wednesday, maintained that the proposed order gave the church the option of removing the redactions or providing a cover sheet for each file. The church chose to remove the redactions because it was too confusing to prepare cover sheets, Hennigan said.
A record-breaking $660 million settlement in 2007 set the stage for the release of the personnel files, which contain letters among top church officials, accused priests and archdiocese attorneys, complaints from parents, medical and psychological records and ? in some cases ? correspondence with the Vatican.
A judge's order in 2011 said the church could redact the names of the church hierarchy, but the LA Times and AP intervened earlier this month and another judge ordered the archdiocese to provide more transparency.
The confidential files could be turned over to more than 500 alleged victims as early as next week, said Ray Boucher, the lead attorney for plaintiffs. What's contained in the files is "chilling," Boucher said.
"Every bishop and every vicar of clergy has been so indoctrinated with the view of protecting the church from scandal that they allowed heinous crimes to be committed," he said.
"That's the irony in all of this. In their vain attempts to protect the image of the church, they've tarnished it beyond repair."
Source: http://www.startribune.com/nation/189106131.html
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Email is one of the most effective tools in our modern marketing arsenal. It allows us to reach an enormous number of people with at a low cost and with minimal effort, especially when you consider the historical alternative.
Since the word ?e-mail? was first used in 1982, the medium has undergone significant evolution. The first email, sent by computer engineer Ray Tomlinson in 1971, contained ?something like QWERTYUIOP,? although he?s not at all sure, commenting that ?It is equally likely to have been ?TESTING 1 2 3 4? or any other equally insignificant message.? Either way, it was a simple text string, a far cry from the colorful and interactive emails that will arrive in our inboxes in 2013.
Email technology is improving, and as marketers we would be amiss to not take advantage of it. However, HTML emails aren?t always easy; there are significant differences between how various email clients render your code, there are government regulations and images are often hidden by default.
Here are 11 applicable tips to ensure that your emails engage your subscribers and stand out from the crowd.
1. Use tables.
Responsive design evangelist Ethan Marcotte won?t be happy about this, but facts are facts: there?s simply not enough support for CSS to make the leap from table-based structures yet. While the rest of the Internet moves on, HTML emails are stuck with nested tables to ensure the highest degree of design integrity.
As of now, the best way to set up a centered, fixed-width HTML email involves creating a first table with a width of 100% and adding another table inside of it:
<table width="100%" cellspacing="0" cellpadding="0"> <tbody>? <tr>? <td valign="top" align="center">? <table width="600" cellspacing="0" cellpadding="0" border="0" align="center">? <!-- Your content here! --> </table> </td>? </tr>? </tbody>? </table>
Dust off your <br /> and <p> tags and get coding!
2. Know your restrictions.
While most email services have good support for the majority of HTML and CSS markup, there is a fair amount of scattering across the board on even fairly general issues. Which clients support CSS3?s text-shadow property? How about spacing using margin and its related shorthand?
Funny you should ask! Text-shadow is supported by all clients except for Outlook (all versions, from ?00 to ?13) and margin is supported by most ? except for recent versions of Outlook and Outlook.com, which ignore margin-top/margin-bottom and margin/margin-top, respectively.
What about CSS?s background attribute? Well, it has no support on recent Outlook, Outlook.com or Gmail on Android 2.3.
Long story short: Use Campaign Monitor?s The Ultimate Guide to CSS Support, which is a comprehensive and well-designed list of CSS support in various browsers and email clients.
3. Use inline CSS.
While some clients support CSS in the tag, many (including Gmail) don?t. Make sure you?re coding CSS inline:
This is a styled paragraph that works in all clients!
I agree that it can be a hassle to code an email and then manually make a last-second change to each and every element, so I recommend the HTML email pre-mailer. Write the code between style tags in your header and then run it through this tool, which translates it across all of your various email elements.
Share this: Don?t communicate crucial information with images. Strengthen your email with their presence but don?t rely on it.
4. Assume viewers can?t see images.
Images are disabled by default for most of your subscribers, so you?ll have to cater your designs to them in a few different ways:
5. Maximum width of 600 pixels
Designers frequently contest that many email recipients now have larger displays and, as such, emails should be wider to take advantage of the increased space. This isn?t necessarily the case.
First, many people still use email clients like Outlook and Thunderbird to access their email. For us at BrightTALK, testing has revealed that well over 40% of our emails are opened on some flavor of Outlook, which has quite a bit of chrome in its interface that minimizes the usable space for email preview.
Second, the growing trend of checking email on mobile means that wider emails will be more difficult to read on mobile devices, and therefore quickly redirected to the trash.
Finally, for web-based clients, larger resolutions don?t necessarily mean wider browser windows. Google?s BrowserLabs site shows the percentage of browsers that can see content at various height/width positionings. Only 80% of viewers have a window wider than 1000 pixels, and that drops to 60% at only 1050 pixels.
In short, if you want recipients to see your email as you designed it, cap the width at 600 pixels.
6. Design with the reader in mind
This is a general design axiom, but is very much applicable to HTML emails as well. Examine your audience for various characteristics, including email client, profession, social media activity and any other distinguishing factors that you might be able to think of.
As you create your list of characteristics, examine the tools at your disposal and make notes on how best to cater your mailings. For example, if you frequently send to new subscribers who use Outlook or Gmail, two clients that don?t show images by default, you might think about minimizing the number of images in your emails in order to make them appear more correctly to new recipients.?To examine if it?s worth including a Twitter link, you might check a portion of your email list against the Twitter email address tool? to determine if there is a high enough percentage of users.
7. CAN-SPAM compliance
The CAN-SPAM Act, which was passed in 2003 by the 108th US Congress, is a law that defines rules for commercial email in order to protect our poor inboxes. There are seven primary rules, and all are entirely reasonable, if not totally intuitive. The following is excerpted from the CAN-SPAM page at the Bureau of Consumer Protection at the Federal Trade Commission:
8. Test compatibility
The first thing to do is determine what type of clients, web-based or otherwise, your recipients use to view your email. As you set up templates, test and refine them constantly, even if it means setting up a PC and a Mac next to each other to check emails with different versions of software.
9. Optimize, optimize, optimize
Your first email isn?t going to be perfect, and neither is your second. Be sure to implement analytics on your emails and examine open rates, click-through rates and ?goal conversion? rates for each email.
Industry standards dictate that you implement A/B or multivariate testing on your emails. For each send, create two emails with slight differences and segment your email list into three sections. Send one version of the email to a quarter of the list and the other email to another quarter; the email with the higher conversion rate should then be sent to the remaining 50% of the list.
Make a note of best practices for subject line composition, send time and day, calls to action and email layout to continually improve the performance of your email.
President Barack Obama?s campaign team did an exceptional job of A/B testing, which resulted in an inspiring story on BusinessWeek.
10. Include a text-only version
Although this may seem outdated, there are a few very valid reasons for which to send a text-only email alongside the full HTML version.
First, some email clients and mobile devices still can?t handle HTML email. Even if it?s just 1% of your send list, you don?t want to miss out an opportunity to connect with your messaging.
Second, SPAM filters still like seeing that there?s a plain text option. If it?s missing, or if the content differs significantly from that of the HTML email, a red flag will be thrown up and might negatively impact the deliverability.
11. Keep it small
Just as with web design, be sure to optimize all of your images before including them in a custom email. It?s bad practice to resize images with HTML for a variety of reasons:
Mobile phone email clients will download images automatically, but don?t have the kind of speed (even with 4G LTE) that you would expect from a desktop computer. The smaller you can make your images, the more seamlessly they?ll display on all clients, browsers and device types and the better your recipients? experience will be.
HTML emails are a complex, though useful, method of communication. Done correctly, they give you the ability to reach into thousands of inboxes with elegant and colorful messaging; done incorrectly, they can drive away potential customers. Track your results, optimize your emails accordingly and pay attention to these eleven keys to a successful HTML email.
Interested in more email marketings tips and strategies? Head over to our marketing community and check out our email marketing webinars.
Source: http://www.business2community.com/online-marketing/eleven-keys-to-a-successful-html-email-0390629
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The five richest people in Los Angeles (according to the LA Business Journal [sub. req.]) come from all walks of life: they are rich doctors, rich developers, rich entertainment executives, and more. Altogether they're worth about $29 billion according to the LABJ and Google calculator (or something like 500 million times the net worth of all of Echo Park). So of course they get up to some delightful real estate exploits. Let's take a look:
5. Ron Burkle
Burkle made his money in supermarkets (he's worth $4.5 billion) and is maybe best known for partying with Bill Clinton on his private jet. His famously opulent Beverly Hills house, Greenacres, has hosted a ridiculous number of Democratic fundraisers and for a while there had a room designated just for Bill. In an account in a recent profile in the New Yorker (sub. req.), the then-president said one night "How is it that when I come out to this house, and all this splendor, when I get back on the plane I feel like I'm going back to public housing?" The same story says Burkle paid $17.5 million for the house in the early '90s (other sources vary by a few million dollars). Greenacres was originally built in 1929 by silent film star Harold Lloyd and is notorious as perhaps the most over-the-top movie star estate of all time--it covered 15 acres and included the main mansion (designed by Sumner Spaulding), a golf course, a stream stocked with fish, stables, an open-air theater, and an enormous swimming pool. It was subdivided in the late '70s, but the mansion was sold on a smaller lot.
Burkle also owns another very famous property, the Frank Lloyd Wright-designed Ennis House in Los Feliz (seen in Blade Runner and a million other movies). He bought the house in 2011 for $4.5 million after guaranteeing a construction loan (the Ennis's textile blocks are very difficult to maintain).
4. David Geffen
David Geffen, who founded Geffen Records and DreamWorks SKG, is worth $4.8 billion, and he would like all of you plebs to please stay away from his beach, ok? He waged a delightful/infuriating battle for decades with the California Coastal Commission over allowing public access by his compound on Carbon Beach (part of the beach is guaranteed public by state law). According to a 2005 NY Times story, "Mr. Geffen had agreed to allow a pathway to run alongside his property in 1983 in exchange for state permission to add a swimming pool and other expansions. But in 2002 he filed a lawsuit to fight the public's right to gain access to the beach at that spot." Finally in 2007, Geffen agreed to open up part of the beach in exchange for a 10-foot privacy buffer. Geffen also appears to own a place on Angelo Drive in Beverly Hills.
In other amusements, there's the story of Geffen and Cher trying to forcibly move Sonny Bono out of the historic Owlwood estate in the 1970s.
3. Kirk Kerkorian
Kerkerorian started out as one of the most important early developers/landowners in Las Vegas (he's also owned MGM and parts of several car companies) and is worth $5.2 billion. He owned a drama-plagued estate in Benedict Canyon at various times--he sold it to Sylvester Stallone in 1990, then bought it back from him in 1997, and Sonny Bono owned part of it at one time. Kerkorian changed the address to slip it into the 90210 zip code, then eventually attempted to sell the 30-acre property (with three houses, two tennis courts, and a putting green) in the mid-aughts for $25 million. He eventually did offload it, although it's not clear for how much. One house hosted season three of the Bad Girls Club and one eventually caught on fire. Kerkorian appears to still own a mansion on Beverly Hills's North Roxbury Drive.
2. Eli Broad
LA's foremost philanthropist/museum-builder made his money building suburban developments with KB Home and is worth $6.6 billion. The ever-reliable Real Estalker reports that "his primary residence is a 10,090 square foot Frank Gehry designed mansion on Oakmont Drive--arguably Brentwood's most exclusive residential street," and that he also owns a Richard Meier in Malibu (near Geffen's house). In 2009, W visited the Brentwood house for an Art Basel party: visitors entered "through a private sculpture park, then entered a sitting room the size of a hotel lobby before descending a stairway into a series of double-height galleries. 'This is bigger than the Gagosian Gallery,' said fashion-world fixture Richard Buckley as he arrived at the first subterranean white cube, with its cranelike Calder sculpture and pair of giant Chuck Close portraits." It apparently also houses one of those enormous metal Richard Serra sculptures.
1. Patrick Soon-Shiong
Perenially richest guy Soon-Shiong is a doctor who made his fortune in pharmaceuticals; he's worth $8 billion as of last spring. He's been pissing off a quiet "upper-middle-class" area of Brentwood (below Sunset!) for the past few years with his construction of a roughly three-acre compound. Soon-Shiong lived in the neighborhood when he was merely rich (not superrich) and in 2006 he started buying up house after house, eventually laying down about $29 million. Back in 2010, the LA Times reported that "crews have been moving dirt, filling in pools and erecting building frames. Trees have been uprooted and moved to other locations. One immense wood-sided hole appears to reflect the footprint of a planned 3,300-square-foot basement ... part of an addition to an existing single-family home that would grow to 18,000 square feet." Meanwhile, more neighbors said that they'd rejected offers to sell to agents believed to be representing Soon-Shiong. Construction back then was estimated to take several years, but meanwhile Soon-Shiong and his family were living "amid it all on a 0.6-acre property."
? Whale Week 2013 [Curbed LA]
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Jan. 29, 2013 ? Working with patients with electrodes implanted in their brains, researchers at the University of California, Davis, and The University of Texas Health Science Center at Houston (UTHealth) have shown for the first time that areas of the brain work together at the same time to recall memories. The unique approach promises new insights into how we remember details of time and place.
"Previous work has focused on one region of the brain at a time," said Arne Ekstrom, assistant professor at the UC Davis Center for Neuroscience. "Our results show that memory recall involves simultaneous activity across brain regions." Ekstrom is senior author of a paper describing the work published Jan. 27 in the journal Nature Neuroscience.
Ekstrom and UC Davis graduate student Andrew Watrous worked with patients being treated for a severe seizure condition by neurosurgeon Dr. Nitin Tandon and his UTHealth colleagues.
To pinpoint the origin of the seizures in these patients, Tandon and his team place electrodes on the patient's brain inside the skull. The electrodes remain in place for one to two weeks for monitoring.
Six such patients volunteered for Ekstrom and Watrous' study while the electrodes were in place. Using a laptop computer, the patients learned to navigate a route through a virtual streetscape, picking up passengers and taking them to specific places. Later, they were asked to recall the routes from memory.
Correct memory recall was associated with increased activity across multiple connected brain regions at the same time, Ekstrom said, rather than activity in one region followed by another.
However, the analysis did show that the medial temporal lobe is an important hub of the memory network, confirming earlier studies, he said.
Intriguingly, memories of time and of place were associated with different frequencies of brain activity across the network. For example, recalling, "What shop is next to the donut shop?" set off a different frequency of activity from recalling "Where was I at 11 a.m.?"
Using different frequencies could explain how the brain codes and recalls elements of past events such as time and location at the same time, Ekstrom said.
"Just as cell phones and wireless devices work at different radio frequencies for different information, the brain resonates at different frequencies for spatial and temporal information," he said.
The researchers hope to explore further how the brain codes information in future work.
The neuroscientists analyzed their results with graph theory, a new technique that is being used for studying networks, ranging from social media connections to airline schedules.
"Previously, we didn't have enough data from different brain regions to use graph theory. This combination of multiple readings during memory retrieval and graph theory is unique," Ekstrom said.
Placing electrodes inside the skull provides clearer resolution of electrical signals than external electrodes, making the data invaluable for the study of cognitive functions, Tandon said. "This work has yielded important insights into the normal mechanisms underpinning recall, and provides us with a framework for the study of memory dysfunction in the future."
Additional authors of the study are Chris Connor and Thomas Pieters at the UTHealth Medical School. The work was supported by the Sloan Foundation, the Hellman Foundation and the NIH.
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WASHINGTON (Reuters) - Outgoing U.S. Secretary of State Hillary Clinton on Tuesday cast doubt on speculation she might run for the White House in 2016.
In an interview taped for National Public Radio, Clinton was asked what questions she needs to answer for herself as she decides whether to run for president.
"I'm not even posing those questions. I am really looking forward to stepping off the fast track that I've been on. I've been out of politics as Secretary of State. I don't see myself getting back into politics," she said, according to an excerpt of the interview.
Whether this is her last word on the subject is unknown. She will face strong pressure from Democrats to join the field of contenders. Clinton will step down this week, following Senate confirmation Tuesday of Massachusetts Democratic Senator John Kerry as her successor.
Those close to Clinton are eager for her to announce a 2016 run, so much so that a group has already formed a new super PAC and registered with the Federal Election Commission on Friday, called "Ready for Hillary."
In 2008, she lost to President Barack Obama in a bitter Democratic primary campaign to be the party nominee for the White House.
Although Clinton, 65, did not categorically rule out another presidential run, in a separate NBC interview she said that she was healthy enough to wage a campaign.
"I have no doubt that I am healthy enough and my stamina is great enough and I'll be fully recovered to do whatever I choose to do," Clinton told "Andrea Mitchell Reports" in an interview that aired on Tuesday.
Clinton was hospitalized in December after doctors found a blood clot stemming from a concussion she suffered previously.
She intends to do more public speaking and writing, and work alongside her husband, former President Bill Clinton, and daughter Chelsea on "mutual foundation interests," she said in the NPR interview.
"I want to be involved in philanthropy, advocacy, working on issues - like women and girls - that I care deeply about," Clinton said.
(Reporting by Margaret Chadbourn; Editing by Cynthia Osterman)
Source: http://news.yahoo.com/clinton-says-she-doesnt-see-getting-back-politics-015239548.html
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My dad and I weren't close. I always felt loved and supported but we didn't really talk and he wasn't particularly involved in my life. I remember when he moved out of home, I was turning 17. He never talked to me about it. He just moved out. I sat in my room listening to music.
He is a man of few words, with a large stature and a strong presence. I've observed the intimidating affect this can have on others. He likes to drink and it's his way of connecting. He's a man with a big heart though; has a lot of compassion.
When I was in my early-20's, we got drunk together on wine and he told me how he was upset that I rarely visited or called him after he moved out and how that was a difficult time in his life. I told him that I was the child in that situation and there was no support given to me. I expressed all the things I was dealing with during that time that he was clueless about. A time later, we both admitted our faults during that period and moved on.
I didn't rely on him emotionally but I did want to gain his approval. Being a man of few words, I've rarely heard words of encouragement from him but those moments that I have, I distinctly remember. I've since let that need for approval fall by the wayside. I'm good. I don't need that from him. I've asked his advice/insight with major decisions in life. I might not necessarily follow his advice but I do respect it. My husband highly respects my dad too.
But I would liken my husband more to my grandad. He likes to talk to people and is genuinely interested in others. He'll talk and laugh and his presence puts people at ease. He rarely drinks. He connects through conversation and making others feel welcomed and included.
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This undated image released by Fuse shows Rick Kaplan. The Fuse television network has turned to news veteran Rick Kaplan, who has run CNN and MSNBC and produced programs like "Nightline," to develop a music news program aimed largely at people some 40 years younger than him. "Fuse News" is set to debut Feb. 6 at 8 p.m. ET with pre-Grammy Awards coverage. The half-hour show, originating from Fuse's studios across from Madison Square Garden in Manhattan, will be repeated at midnight. (AP Photo/Fuse)
This undated image released by Fuse shows Rick Kaplan. The Fuse television network has turned to news veteran Rick Kaplan, who has run CNN and MSNBC and produced programs like "Nightline," to develop a music news program aimed largely at people some 40 years younger than him. "Fuse News" is set to debut Feb. 6 at 8 p.m. ET with pre-Grammy Awards coverage. The half-hour show, originating from Fuse's studios across from Madison Square Garden in Manhattan, will be repeated at midnight. (AP Photo/Fuse)
This undated image released by Fuse shows Rick Kaplan. The Fuse television network has turned to news veteran Rick Kaplan, who has run CNN and MSNBC and produced programs like "Nightline," to develop a music news program aimed largely at people some 40 years younger than him. "Fuse News" is set to debut Feb. 6 at 8 p.m. ET with pre-Grammy Awards coverage. The half-hour show, originating from Fuse's studios across from Madison Square Garden in Manhattan, will be repeated at midnight. (AP Photo/Fuse)
NEW YORK (AP) ? The Fuse television network has turned to news veteran Rick Kaplan, who has run CNN and MSNBC and produced programs like "Nightline," to develop a music news program aimed largely at people some 40 years younger than him.
"Fuse News" is set to debut Feb. 6 at 8 p.m. Eastern time with pre-Grammy Awards coverage. The half-hour show, originating from Fuse's studios across from Madison Square Garden in Manhattan, will be repeated at midnight.
"A lot of people are covering music in different ways," said Mike Bair, president of MSG Media, Fuse's corporate ownership. "But not a lot of people are covering it deeper and in a respectful way. We thought there was a real opportunity for us."
Fuse, available in some 70 million homes, is overshadowed by MTV, but unlike its competitor has kept its focus on music and is looking for a signature show.
Kaplan, 65, walked through a busy newsroom with TVs tuned to a Fuse countdown of sexy rap videos one recent afternoon. The 47-time Emmy winner had most recently produced Katie Couric's "CBS Evening News" and Christiane Amanpour's stint on ABC's Sunday morning and has formed his own consulting company.
Bair reached out to Kaplan through a mutual friend to gauge interest, and the idea intrigued Kaplan.
"While he's not in the target audience for Fuse (the network's median age is around 27), I think he also saw the opportunity," Bair said.
A whiteboard in Fuse's office already lists story plans for the first month. The collapse of the traditional music industry has made for many changes ripe for examining.
One future story will talk about bands scalping tickets to their own concerts, another about the sound quality issues behind the resurgence of vinyl. If "Fuse News" was on the air last week, it wouldn't treat the story about Beyonce lip-synching at the inauguration as a joke, but rather look into how widespread the practice is, Kaplan said.
"I want it to be a place where if you're involved in the industry in any way ? and that means anybody with a headset ? this will be the place where you will want to go," Kaplan said.
Kaplan's tastes run to the Eagles, the Beatles and the Rolling Stones. Now he's learning about electronic dance music, and even liking some of it. Liz Walaszczyk, a 28-year-old producer and contributing correspondent on "Fuse News," is gently introducing her boss to bands like the Xx.
And he's introducing her to the news.
Walaszczyk, who booked bands for Carson Daly's NBC show before joining Fuse, said that she finds blogs like Pitchfork and Stereogum helpful but that there's a void in serious music journalism. Kaplan is teaching her the importance of detail in every question asked and picture selected for her stories.
"I hear his voice and I think, 'This man has spoken to so many legends,'" she said.
Co-anchors for the show are Alexa Chung and Matte Babel. Former Gawker writer Elaine Moran and Jack Osbourne are contributing correspondents.
Yes, the news producer who once worked with Walter Cronkite is telling Ozzy's kid what to do.
Kaplan brushed aside a question about whether some people in the television news business might consider his current gig a comedown.
"Oh, God no," he said. "By no means. People who say that don't get it. It's a great privilege to be asked to do this program. It's the only serious program in this industry. It's a serious attempt to report on music in a credible way."
He said he's having a blast.
"In many ways, what Fuse is attempting to do with this show is more cutting edge than what any of the networks are doing," he said. "We're not starting a magazine show. We're not tinkering with the evening news."
The show will also have studio guests and music performances. Kaplan has hired Audrey Gruber, a former CBS News and CNN producer, to eventually take over for him when the show is up and running.
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DALLAS (Reuters) - Boy Scouts of America is considering ending a longstanding national ban on gay youth and adult members and leaving policies on sexual orientation to its local organizations, a spokesman said on Monday.
Lifting the ban would mark a dramatic reversal for the 103-year-old organization, which only last summer reaffirmed its policy amid heavy criticism from gay rights groups and some parents of scouts.
The organization's national executive board is expected to discuss lifting the ban on gay members at its regularly scheduled board meeting next week in Texas.
"The policy change under discussion would allow the religious, civic or educational organizations that oversee and deliver Scouting to determine how to address this issue," spokesman Deron Smith said in an email to Reuters.
The Church of Jesus Christ of Latter-day Saints, the United Methodist Church and the Catholic Church have the largest youth membership in the Boy Scouts among faith-based organizations.
The organization, which had more than 2.6 million youth members and more than 1 million adult members at the end of 2012, "would not, under any circumstances, dictate a position to units, members, or parents," Smith said.
The Boy Scouts has also faced criticism for keeping private files covering decades of child sex abuse incidents within the organization. The Scouts released thousands of pages of files in October covering incidents from 1965 to 1985.
The Boy Scouts won a 5-4 U.S. Supreme Court ruling allowing the organization to ban gays in 2000, but has come under increasing public pressure in recent years from activists. They include Zach Wahls, an Eagle Scout with two lesbian mothers, and Jennifer Tyrrell, a lesbian mother from Ohio who was ousted as a Scout den leader and treasurer.
"This is absolutely a step in the right direction," said Wahls, who is founder of Scouts for Equality, a group that includes 3,151 other Eagle scouts.
Wahls said he would turn to persuading local councils to enact nondiscrimination policies if the change is approved.
Tyrrell said she looked forward to a day when she and her family might participate in scouting again.
"An end to this ban will restore dignity to countless families across the country, my own included, who simply wanted to take part in all Scouting has to offer," Tyrrell said in a statement.
GLAAD, an anti-discrimination advocacy group, began to press for a reversal of the Boy Scouts policy after Tyrrell was removed from her son's den and more than 1 million people have signed petitions on Change.org seeking an end to the policy.
More than 462,000 people signed a petition on Change.org calling for the Boy Scouts to grant an Eagle Scout application for Ryan Andresen, a California resident who is openly gay.
Andresen's scoutmaster refused to sign the application because of his sexual orientation. A review board for the California chapter recommended he receive the rank, but its recommendation was never forwarded to national headquarters.
The organization has faced pressure from board members - Ernst & Young chairman and chief executive Jim Turley and AT&T chief executive Randall Stephenson have spoken out against the ban - and some corporations withdrew support over the policy.
United Parcel Service was among corporations that have said they would pull funding from the organization over its policy.
The Family Research Council, which said in December it would pull its business with UPS because the package delivery company had decided to cease funding of the Boy Scouts, said on Monday the Scouts should resist the pressure to change its policy.
"If the board capitulates to the bullying of homosexual activists, the Boy Scouts' legacy of producing great leaders will become yet another casualty of moral compromise," Family Research Council President Tony Perkins said in a statement.
Patrick Boyle, whose 1994 book "Scout's Honor" was among the first to examine sexual abuse in the Boy Scouts of America, said on Monday the "striking reversal in policy" was likely the result of growing pressure from corporations.
"This is a safe way out of this mess for the national organization, which takes the fight back to the local level, and says to a local leader, 'you make the choice that's right for you'," Boyle said. "It's essentially the Boy Scouts' version of states' rights."
(Additional reporting by Ian Simpson, Barbara Liston and Chris Francescani; Writing by Greg McCune and David Bailey; Editing by Paul Thomasch and Andrew Hay)
Source: http://news.yahoo.com/boy-scouts-america-says-discussing-end-ban-gay-183918053.html
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ROME (Reuters) - Former prime minister Silvio Berlusconi triggered outrage from Italy's political left on Sunday with comments defending fascist wartime leader Benito Mussolini at a ceremony commemorating victims of the Nazi Holocaust.
Speaking at the margins of the event in Milan, Berlusconi said Mussolini had been wrong to follow Nazi Germany's lead in passing anti-Jewish laws but that he had in other respects been a good leader.
"It's difficult now to put yourself in the shoes of people who were making decisions at that time," said Berlusconi, who is campaigning for next month's election at the head of a coalition that includes far-right politicians whose roots go back to Italy's old fascist party.
"Obviously the government of that time, out of fear that German power might lead to complete victory, preferred to ally itself with Hitler's Germany rather than opposing it," he said.
"As part of this alliance, there were impositions, including combating and exterminating Jews," he told reporters. "The racial laws were the worst fault of Mussolini as a leader, who in so many other ways did well," he said, referring to laws passed by Mussolini's fascist government in 1938.
Although Mussolini is known outside Italy mostly for the alliance with Nazi Germany, his government also paid for major infrastructure projects as well as welfare for supporters.
Berlusconi's comments overshadowed Sunday's commemoration of thousands of Jews and others deported from Italy to the Nazi death camps of eastern Europe. They were condemned as "disgusting" by the center-left Democratic Party (PD), which is leading in the polls ahead of the February 24-25 election.
"Our republic is based on the struggle against Nazi fascism and these are intolerable remarks which are incompatible with leadership of democratic political forces," said Marco Meloni, the PD's spokesman for institutional affairs.
Antonio Ingroia, a former anti-mafia magistrate campaigning at the head of a separate left-wing coalition, said Berlusconi was "a disgrace to Italy".
AMBIGUOUS
Faced by the onslaught of criticism, Berlusconi later issued a statement saying he had always condemned dictatorships and regretted not having spelled that out in his earlier remarks.
"There can be no misunderstanding about the fascist dictatorship," he said, accusing the left of capitalizing on his earlier comments for cheap political gain.
However, it was not the first time Berlusconi has defended Mussolini, whose status in Italy remains deeply ambiguous 67 years after he was executed by communist partisans while trying to flee to Switzerland in April, 1945.
Many Italian politicians, including the speaker of the Lower House of parliament, Gianfranco Fini, come from the ranks of the old Italian Social Movement (MSI) which grew out of the fascist party, although Fini and others have renounced the far right.
Others, including Francesco Storace, Berlusconi's candidate for president of the Lazio region, have stayed true to what they see as the "social-right" tradition of the fascist movement.
Monuments to Mussolini, who came to power in 1922, still dot many Italian cities, including Rome, where a column to Il Duce stands close to the city's main football stadium, within a stone's throw of the foreign ministry.
Although never as fervently anti-semitic as his Nazi allies, Mussolini's government persecuted Italy's Jewish population, which was then estimated to number about 40,000, according to the Jewish Contemporary Documentation Centre in Milan.
The 1938 laws imposed oppressive restrictions on Jews and some 10,000 are estimated to have been deported from Italy between September 1943 and March 1945. Most of them died in the Auschwitz concentration camp in Poland.
While anti-semitic behavior has not been as prominently reported in Italy in recent years as in neighboring countries such as France, acts ranging from anti-Jewish graffiti to chants at football matches occur periodically.
"We must be very careful to ensure that these sparks, which recur every now and then, cannot bring back tragedies which humanity should not suffer again," outgoing Prime Minister Mario Monti said on Sunday.
(Editing by Louise Ireland)
Source: http://news.yahoo.com/berlusconi-defends-mussolini-draws-outrage-political-left-152535156.html
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Mariah Arostigue, left, and Noah Reyes, 11th graders, chat as they work on their homework in a pre-calculus class at Segerstrom High School in Santa Ana, Calif., Wednesday, Jan. 16, 2013. A growing number of teachers are implementing what is known as "flipped learning," in which students learn lessons as homework, mostly through online videos produced by teachers, and use classroom time to practice what they learned. (AP Photo/Jae C. Hong)
Mariah Arostigue, left, and Noah Reyes, 11th graders, chat as they work on their homework in a pre-calculus class at Segerstrom High School in Santa Ana, Calif., Wednesday, Jan. 16, 2013. A growing number of teachers are implementing what is known as "flipped learning," in which students learn lessons as homework, mostly through online videos produced by teachers, and use classroom time to practice what they learned. (AP Photo/Jae C. Hong)
Students solve problems in Crystal Kirch's pre-calculus class at Segerstrom High School in Santa Ana, Calif., Wednesday, Jan. 16, 2013. A growing number of teachers are implementing what is known as "flipped learning," in which students learn lessons as homework, mostly through online videos produced by teachers, and use classroom time to practice what they learned. (AP Photo/Jae C. Hong)
Teacher Crystal Kirch, center, talks to her students in her pre-calculus class at Segerstrom High School in Santa Ana, Calif., Wednesday, Jan. 16, 2013. A growing number of teachers are implementing what is known as "flipped learning," in which students learn lessons as homework, mostly through online videos produced by teachers, and use classroom time to practice what they learned. (AP Photo/Jae C. Hong)
Marisa Wilkerson, 11th grader, and her classmate use their hands to make the shape of a conic section in Crystal Kirch's pre-calculus class at Segerstrom High School in Santa Ana, Calif., Wednesday, Jan. 16, 2013. A growing number of teachers are implementing what is known as "flipped learning," in which students learn lessons as homework, mostly through online videos produced by teachers, and use classroom time to practice what they learned. (AP Photo/Jae C. Hong)
Teacher Crystal Kirch greets her student in her pre-calculus class at Segerstrom High School in Santa Ana, Calif., Wednesday, Jan. 16, 2013. A growing number of teachers are implementing what is known as "flipped learning," in which students learn lessons as homework, mostly through online videos produced by teachers, and use classroom time to practice what they learned. (AP Photo/Jae C. Hong)
SANTA ANA, Calif. (AP) ? When Timmy Nguyen comes to his pre-calculus class, he's already learned the day's lesson ? he watched it on a short online video prepared by his teacher for homework.
So without a lecture to listen to, he and his classmates at Segerstrom Fundamental High School spend class time doing practice problems in small groups, taking quizzes, explaining the concept to other students, reciting equation formulas in a loud chorus, and making their own videos while teacher Crystal Kirch buzzes from desk to desk to help pupils who are having trouble.
It's a technology-driven teaching method known as "flipped learning" because it flips the time-honored model of classroom lecture and exercises for homework ? the lecture becomes homework and class time is for practice.
"It was hard to get used to," said Nguyen, an 11th-grader. "I was like 'why do I have to watch these videos, this is so dumb.' But then I stopped complaining and I learned the material quicker. My grade went from a D to an A."
Flipped learning apparently is catching on in schools across the nation as a younger, more tech-savvy generation of teachers is moving into classrooms. Although the number of "flipped" teachers is hard to ascertain, the online community Flipped Learning Network now has 10,000 members, up from 2,500 a year ago, and training workshops are being held all over the country, said executive director Kari Afstrom.
Under the model, teachers make eight- to 10-minute videos of their lessons using laptops, often simply filming the whiteboard as the teacher makes notations and recording their voice as they explain the concept. The videos are uploaded onto a teacher or school website, or even YouTube, where they can be accessed by students on computers or smartphones as homework.
For pupils lacking easy access to the Internet, teachers copy videos onto DVDs or flash drives. Kids with no home device watch the video on school computers.
Class time is then devoted to practical applications of the lesson ? often more creative exercises designed to engage students and deepen their understanding. On a recent afternoon, Kirch's students stood in pairs with one student forming a cone shape with her hands and the other angling an arm so the "cone" was cut into different sections.
"It's a huge transformation," said Kirch, who has been taking this approach for two years. "It's a student-focused classroom where the responsibility for learning has flipped from me to the students."
The concept emerged five years ago when a pair of Colorado high school teachers started videotaping their chemistry classes for absent students.
"We found it was really valuable and pushed us to ask what the students needed us for," said one of the teachers, Aaron Sams, now a consultant who is developing on online education program in Pittsburgh. "They didn't need us for content dissemination, they needed us to dig deeper."
He and colleague Jonathan Bergmann began condensing classroom lectures to short videos and assigning them as homework.
"The first year, I was able to double the number of labs my students were doing," Sams said. "That's every science teacher's dream."
In the Detroit suburb of Clinton Township, Clintondale High School Principal Greg Green converted the whole school to flipped learning in the fall of 2011 after years of frustration with high failure rates and discipline problems. Three-quarters of the school's enrollment of 600 is low-income, minority students.
Flipping yielded dramatic results after just a year, including a 33 percent drop in the freshman failure rate and a 66 percent drop in the number of disciplinary incidents from the year before, Green said. Graduation, attendance and test scores all went up. Parent complaints dropped from 200 to seven.
Green attributed the improvements to an approach that engages students more in their classes.
"Kids want to take an active part in the learning process," he said. "Now teachers are actually working with kids."
Although the method has been more popular in high schools, it's now catching on in elementary schools, said Afstrom of the Flipped Learning Network.
Fifth-grade teacher Lisa Highfill in the Pleasanton Unified School District said for a lesson about adding decimals, she made a five-minute, how-to video kids watched at home and in class, then she distributed play money and menus and had kids "ordering" food and tallying the bill and change.
A colleague who teaches kindergarten reads a storybook on video. The video contains a pop-up box that requires kids to write something that shows they understood the story.
The concept has its downside. Teachers note that making the videos and coming up with project activities to fill class time is a lot of extra work up front, while some detractors believe it smacks of teachers abandoning their primary responsibility of instructing.
"They're expecting kids to do the learning outside the classroom. There's not a lot of evidence this works," said Leonie Haimson, executive director of Class Size Matters, a New York City-based parent advocacy group. "What works is reasonably sized classes with a lot of debate, interaction and discussion."
Others question whether flipped learning would work as well with low achieving students, who may not be as motivated to watch lessons on their own, but said it was overall a positive model.
"It's forcing the notion of guided practice," said Cynthia Desrochers, director of the Center for Excellence in Learning and Teaching at California State University-Northridge. "Students can get the easy stuff on their own, but the hard stuff should be under the watchful eye of a teacher."
At Michigan's Clintondale High School, some teachers show the video at the beginning of class to ensure all kids watch it and that home access is not an issue.
In Kirch's pre-calculus class, students said they liked the concept.
"You're not falling asleep in class, "said senior Monica Resendiz said. "You're constantly working."
Explaining to adults that homework was watching videos was a little harder, though.
"My grandma thought I was using it as an excuse to mess around on the Internet," Nguyen said.
___
Contact the reporter at http://twitter.com/ChristinaHoag .
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A protester throws a tear gas canister back at riot police during clashes near Tahrir Square, in Cairo, Sunday, Jan. 27, 2013. Clashes continued for the fourth successive day between protesters and police near Tahrir square, birthplace of the 2011 uprising. Police used tear gas, while the protesters pelted them with rocks. (AP Photo/Khalil Hamra)
A protester throws a tear gas canister back at riot police during clashes near Tahrir Square, in Cairo, Sunday, Jan. 27, 2013. Clashes continued for the fourth successive day between protesters and police near Tahrir square, birthplace of the 2011 uprising. Police used tear gas, while the protesters pelted them with rocks. (AP Photo/Khalil Hamra)
People carry the coffin of a man killed during a mass funeral in Port Said, Egypt, Sunday, Jan. 27, 2013. Tens of thousands of mourners poured into the streets of Port Said on Sunday for a funeral for most of the 37 people killed in rioting a day earlier, chanting slogans against Islamist President Mohammed Morsi. (AP Photo)
WASHINGTON (AP) ? Egypt is on a "difficult path" to a peaceful democracy, the White House said Monday as months of lukewarm political support for the conservative Islamic government was in danger of backfiring after deadly weekend riots pushed Cairo to crack down on civil rights.
It was the latest strain on the stretched-thin detente between the Obama administration and Egyptian President Mohammed Morsi and his Muslim Brotherhood following ? a fault line that already has delayed $1 billion in U.S. aid to Cairo. Billions of additional dollars in international loans also have been shelved because of Egypt's instability.
Washington has worried since June ? when Egyptian voters overthrew dictator Hosni Mubarak and picked Morsi as its first democratically elected leader ? that the Brotherhood ultimately would default to its anti-American and anti-Israel roots instead of taking a more moderate stance towards peace.
A spate of recent steps ? from Brotherhood-led attacks on protesters, to vague protestations of women's freedoms in the nation's new constitution, to revelations of old comments by Morsi referring to Jews as "bloodsuckers" and "pigs" ? have raised alarm among senior U.S. officials. Political unrest in Egypt peaked this weekend with clashes that left more than 50 people dead and forced Morsi to deploy military forces and impose a curfew as part of a month-long state of emergency in three Suez Canal provinces.
"We have engaged directly with the Egyptian government as they move forward on the difficult path towards greater democracy and rule of law, and we will continue to do so," White House spokesman Jay Carney said Monday. "There needs to be a lasting solution to the conflict that we see in Egypt and it has to be a solution that adheres to the rights of all Egyptians.
"Obviously, this is not a lasting solution," Carney said.
The U.S. Embassy in Cairo closed hours early on Monday, fearing that protests against Morsi and the Brotherhood could turn violent and endanger American diplomats who work a few miles from Tahrir Square, the base of Egypt's revolution in 2001. State Department spokeswoman Victoria Nuland said U.S. officials are "obviously watching how this moves forward," and urged Morsi's secular and liberal political opponents to agree to a national dialogue with the president to settle the burgeoning crisis.
"There are a lot of different views about how to take the country forward," Nuland said.
Egypt is the birthplace of the Muslim Brotherhood, but its influence and affiliates have spread across the Mideast and into North Africa ? where two recent terrorist attacks and a French assault on Islamist militants in Mali have presented Obama with a new front in the war against extremism for his second term.
The White House has little interest in picking a fight with the Brotherhood, which has grown in size and stature across the region since the Arab Spring revolts. The Brotherhood and similar Islamist movements are regarded warily by monarchies in Jordan, Kuwait, Saudi Arabia, the United Arab Emirates and Morocco. Its members are part of the opposition coalition seeking to oust Syrian President Bashar Assad. It has small followings in Qatar, Algeria, and a like-minded ? although not officially affiliated ? ally in Tunisia.
The Brotherhood describes itself as a non-violent social organization dedicated to instilling Islamic values in the society. In Egypt, the group was repressed by former regimes for decades and has struggled with adjusting to its new role leading the government. Its members, fearing a coup, are widely blamed with attacking anti-Morsi protesters outside the presidential palace in Cairo last month in clashes that left at least 10 people dead.
"This is the kind of group that will be a pain to deal with for the United States, but it's not al-Qaida; it's not a security threat," said Nathan Brown, a professor at George Washington University who has been researching Islamic movements for nearly a decade. "The biggest fear on the part of the (Obama) administration is a political breakdown in Egypt. They are worried that a collapse in the Egyptian state would be destabilizing on the region, and might allow the flow of arms and fighters among more radical movements in the region."
Since the Tahrir Square revolution, Washington has tried to help Egypt build a democratic state without appearing to tread on its sovereignty. Morsi won election last June with 51 percent of Egypt's vote, and has since offered words of moderation, brokered a cease-fire between Israelis and Palestinians in Gaza and bore down on terrorist dens in the Sinai Peninsula.
Morsi's anti-Semitic comments, made in separate speeches in 2010 but which surfaced this month on Egyptian TV, also accused Obama of being a liar. They shocked U.S. officials who sprang to condemn them as counter-productive to American-supported peace efforts in the Mideast. But they surprised few people in Egypt, who have heard Brotherhood officials make similar statements for years.
Morsi initially struggled to respond to the U.S. backlash from the comments. His office issued a statement committing to uphold religious freedoms and tolerance, and condemning violence. It did little to soothe U.S. lawmakers ? Democrats and Republicans alike ? who have balked at approving $1 billion in aid to Egypt that Obama promised in 2011 to help the new government settle an economic crisis that has drained the country's central bank and devalued the local currency in the revolution's aftermath.
"How would the American people feel about cutting money to education programs here and giving money to a government that is anti-Semitic?" Rep. Frank Wolf, R-Va., a member of the House Appropriations subcommittee that oversees funding to foreign governments, said.
"I don't think the administration has any right to say they are going to grant this foreign aid because I think this Congress may very well condition it," Wolf said. "I think there are a lot of questions, and I don't think it's a given."
Part of the proposed $1 billion aid package depends on International Monetary Fund approval of its own $4.8 billion loan to Egypt. But that loan has stalled for months because of Egypt's instability. And despite its misgivings about Morsi, the White House still is pushing Congress for the funding, acknowledging that Egypt's downfall all but certainly would roil the already turbulent Mideast and North Africa.
Obama administration officials said Morsi's promises to abide by Egypt's 1979 peace treaty with Israel, and continued security cooperation with Israel over the volatile Sinai Peninsula shows his willingness to be a reasonable partner. Morsi's work in November to broker a cease-fire between Israel and Gaza's Hamas rules was "a good first step," the senior Obama administration official said.
But Washington remains wary of Morsi and the Muslim Brotherhood, "who come from a very conservative viewpoint with issues that are very important to America," said Sen. Kirsten Gillibrand, D-N.Y.
Gillibrand was part of a delegation of U.S. lawmakers who met with Morsi in Cairo this month shortly after his 2010 statements surfaced. She stopped short of saying Morsi appeared chastened but described him as mindful of "how important America is to the viability of his presidency and the economy."
She said lawmakers want to see what actions he takes, "and we want to see if his words match those deeds and actions," Gillibrand said.
___
Follow Lara Jakes on Twitter at https://twitter.com/larajakesAP
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TOKYO (AP) ? Now it's official: Toyota is once again the world's top automaker.
Toyota Motor Corp. released its tally for global vehicle sales for last year Monday at a record 9.748 million vehicles ? a bigger number than the estimate it gave last month of about 9.7 million vehicles.
It was already clear Toyota had dethroned General Motors Co. as the Detroit-based automaker fell short, selling 9.29 million vehicles.
GM had been the top-selling automaker for more than seven decades before losing the title to Toyota in 2008.
GM retook the sales crown in 2011, when Toyota's production was hurt by the quake and tsunami in northeastern Japan.
The latest results show Toyota's powerful comeback.
Global vehicle sales for the maker of the Camry sedan, Prius hybrid and Lexus luxury model surged nearly 23 percent from the previous year. Overseas sales jumped 19 percent, while sales in Japan, where the economy has been troubled, recovered a whopping 35 percent.
Volkswagen AG of Germany, the world's No. 3 automaker, sold a record 9.1 million vehicles around the world.
All three automakers play down the significance of the sales ranking and say they are focused on making attractive products.
"Rather than going after numbers, we hope to make fine products, one by one, to keep out customers satisfied. The numbers are just a result of our policy. And our policy will continue unchanged," said Toyota spokeswoman Shino Yamada.
Still, the recovery for Toyota is impressive. Like other Japanese automakers, Toyota's production was devastated by the March 2011 disasters, which disrupted supplies of crucial components. Flooding in Thailand, where Toyota has factories, also hurt car production.
Before that, it struggled against a crisis of massive recalls in the U.S. over defective floor mats, gas pedals and brakes, involving millions of vehicles, some recalled over and over, that hurt its reputation for quality.
Toyota officials have vowed to scrutinize quality, and have held back product development to minimize recalls.
From the middle of last year, it was hit by another kind of problem ? a widespread boycott of Japanese products, including Toyota cars, in China over a territorial dispute.
But sales growth in other parts of the world, including the U.S. and Asian nations such as Indonesia and India, was more than enough to offset such losses.
Toyota is planning to sell 9.91 million vehicles globally in 2013, putting it back on track toward its earlier goal of 10 million vehicles ? a target that it had made a special effort to play down after its recall crisis.
___
Follow Yuri Kageyama on Twitter at www.twitter.com/yurikageyama
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At least 245 people were killed after a band?s fireworks show sparked a rapidly moving fire in a packed nightclub in southern Brazil and fleeing patrons were unable to find their way out, local police told NBC News.
Source: http://www.msnbc.msn.com/id/40153870/vp/50601555#50601555
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DUBAI (Reuters) - Iran has successfully launched a live monkey into space, the state news agency IRNA said on Monday, touting it as an advance in a missile and space program that has alarmed the West and Israel.
There was no independent confirmation of the report, which quoted a defense ministry statement. It said the launch coincided "with the days of" the Prophet Mohammad's birthday last week but gave no date.
IRNA said the monkey was sent into space on a Kavoshgar rocket. The rocket reached a height of more than 120 km (75 miles) and "returned its shipment intact", IRNA reported.
The Islamic Republic's state-run, English-language Press TV said the monkey was retrieved alive.
Iran announced plans in 2011 to send a monkey into space, but that attempt was reported to have failed.
Western powers are concerned that the long-range ballistic technology used to propel Iranian satellites into orbit could be used to launch nuclear warheads. Tehran denies such suggestions and says its nuclear activity is for peaceful energy only.
(Reporting by Yeganeh Torbati; Editing by Mark Heinrich)
Source: http://news.yahoo.com/iran-successfully-launches-monkey-space-report-114115302.html
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PROSPECT HEIGHTS ? A Brooklyn man who escaped police custody while being questioned for a 2010 homicide was feigning a trip to the bathroom when he pushed an officer out of the way and bolted, Police Commissioner Raymond Kelly said Friday.
Read the whole story at DNAinfo
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Jan. 27, 2013 ? The spread of breast cancer to distant organs within the body, an event that often leads to death, appears in many cases to involve the loss of a key protein, according to UC San Francisco researchers, whose new discoveries point to possible targets for therapy.
In the January 27, 2013 online edition of Nature Cell Biology, UCSF scientists describe for the first time how the protein, known as GATA3 -- which is abnormal or absent in many cases of human breast cancer -- normally acts downstream in biochemical pathways to prevent the distant spread of cancer, an event called metastasis.
The discovery points to a biochemical control point that simultaneously holds in check several key events required for tumor cells to successfully spread.
"When GATA3 is present, it turns off many genes that are active in metastasis," said Zena Werb, PhD, a UCSF professor of anatomy who led the research. "We now have identified the molecular mechanisms involved."
The key finding of the new study is that GATA3 acts downstream biochemically to activate a molecule -- obscure until now -- called microRNA29b. MicroRNA29b in turn stops protein production from other genes that play vital roles in metastasis.
The absence or loss of GATA3 can free cancerous cells to break free from their defined roles and tethers within a tumor, to move away from the tumor mass, to induce cancer-promoting inflammation, and to stimulate the development of new blood vessels that can help spreading cancerous cells regrow as tumors in new locations.
"People knew that some of these genes were turned on in some cancers, but they did not know they were turned on because GATA3 and microRNA29b were turned off," Werb said. "If you have 20 genes that are becoming less active all at once due to microRNA29b, it could have a profound effect."
Working with mice, the researchers found that restoring microRNA29b to one of the most deadly types of breast cancer stopped metastasis. But the researchers also found that if they knocked out the microRNA29b, tumors spread even in the presence of GATA3, suggesting that microRNA29b can be the driver of metastasis.
In the mouse models of breast cancer studied by Werb's team, GATA3 normally restrains cancerous cells from breaking away from the main tumor and migrating to other organs.
It might be possible, Werb said, to develop drugs that inhibit breast cancer metastasis by re-activating these controls in cancerous cells that have lost the normal protein.
Many researchers who study early stages of cancer focus on abnormal genes and proteins that cause cells to expand their numbers rapidly, a hallmark of cancer.
However, the ability to spread to distant places and to eventually cause lethal complications requires not only cell division and tumor growth, but also changes in how the cancerous cell negotiates with its surroundings. This relationship must be altered to permit cancer to spread, according to earlier research findings by Werb and others.
"Many of the key processes in cancer that GATA3 suppresses take place outside the cell, in the surrounding environment," she said.
GATA3 is a master control for luminal cells, which line the milk-carrying ducts of the breast. In essence, GATA3 dictates the defining characteristics of a normal breast cell, Werb said.
Luminal breast cancers are the most common form of the disease, and the hormones estrogen and progesterone drive their growth. Loss of the normal GATA3 protein as luminal breast cancers evolve is associated with a greater risk of death, Werb said, and occurs in roughly 10 percent of luminal breast cancer cases.
But, along with many other proteins, GATA3 also is absent in "triple negative," breast cancers, which are more often fatal. Triple negative breast cancers, which disproportionately affect black women and younger women, do not depend on the hormones, nor do they require a third growth factor, called HER2.
Triple negative breast cancers, which account for roughly one-in-five breast cancers, have been more difficult to target successfully with newer treatments.
"The targeting we would like to do is to give back microRNA29b specifically to breast tumor cells to prevent metastasis," Werb said.
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