Friday, 30 November 2012

Die-hard Indonesian gamer and Endeavor Entrepreneur turns ...

Reprinted from Jakarta Globe. Original article here.

By Antonny Saputra

There are hundreds of online games published around the world every day, with dozens of them dubbed ?the most popular? during their brief time in the spotlight.

With millions of die-hard fans spending hours in front of their computers all day long, game publishers can earn millions of dollars in profit through vouchers required for the players to keep playing, or through the sale of advanced items to players to enhance their gameplay.

Amid the sea of Indonesian gamers, one man has managed to find his own fortune within the online-gaming industry.

Vincent Iswaratioso is one of the founders of Indomog, an online company that provides people with an easy payment-solution option to purchase online gaming vouchers.

The website, which he launched with three of his friends in 2007, features an elegant Web layout that is free of unrelated pop-up ads and banners.

It was his success with the business that led Vincent to be chosen as one of three entrepreneurs to represent Indonesia at Endeavor?s 45th International Selection Panel in Istanbul, Turkey last month. Endeavor is an organization that aims to mentor promising entrepreneurs.

Vincent was joined by Niki Luhur, president director of payment-solutions company Kartuku, and Aldi Haryopratomo, chief executive of social enterprise Ruma.

?We attracted entrepreneur candidates from four continents to Istanbul, representing the true breadth of Endeavor?s efforts to identify and support high impact entrepreneurs throughout the world,? said Endeavor co-founder and chief executive Linda Rottenberg.

?After an outstanding ISP in Istanbul, I am thrilled to welcome our first Endeavor Entrepreneurs from Indonesia. We commend Vincent, Niki, and Aldi for their achievements thus far, and look forward to being part of their growth stories in the years to come.?

Vincent and his friends were still testing the waters of Indomog during their first three years of operation.

?It was a trial and error process for us in the beginning. We?ve even changed our management three times,? Vincent said.

Vincent, who is quite the gamer himself, was once among the hundreds of thousands of Ultima Online players when the MMORPG (massively multiplayer online role-playing game) was released in late 1997.

Now, 15 years later, Vincent is helping streamline the process for die-hard players by providing a one-stop solution to access every available popular online game in Indonesia.

?In a way, playing online games is also a form of education. Some adventure games teach you about history and geography and of course the online elements encourages social interaction. This is why I think it?s a mistake to see online gamers as geeks, although console players who only play single-player games may prove to be different,? Vincent said about his support for children and teenagers to play more online games.

As one of the biggest markets for online gaming in Asia, one could wonder why Indonesian publishers don?t consistently develop their own high-profile MMORPG to cover our huge market. Vincent argued that one of the biggest problems people faced here was the fact that capable experts required for the tiny details of game development were all spread out.

?It?s hard to assemble the team,? he said. Established 15 years ago, Endeavor is a non-profit organization that aims to lead the global movement toward accelerating long-term economic growth. This is achieved by monitoring, selecting, mentoring and promoting the best high-impact entrepreneurs around the world.

The organization?s community assists their selected entrepreneurs in overcoming developmental challenges through solid networking, access to smart capital, strategic advising and inspiration from successful world-renowned businessmen and women alike.

Endeavor chooses entrepreneurs like Vincent from around the world, with the hope that these talented people create job opportunities, become role models for others and foster an entrepreneurship ecosystem that promotes investment.

And now with its consistent growth, Endeavor has expanded to 15 different countries including Jordan and Saudi Arabia, with its Indonesian branch launched in February this year.

Vincent was one of the thousands of entrepreneurs Endeavor screened through an intense selection process, which lasted more than 12 months.

Participants had to pass a series of local and regional interviews before presenting themselves to the panelists of its global business network at an international selection panel, which is held four to five times each year.

When people are finally selected as an Endeavor Entrepreneur, they will then receive guidance from mentors who voluntarily dedicate their time.

Endeavor entrepreneurs have created more than 180,000 jobs, contributed billions of dollars into local economies and have become role models for young people in developing economies.

Source: http://www.endeavor.org/blog/die-hard-indonesian-gamer-and-endeavor-entrepreneur-turns-obsession-into-winning-business-plan/

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Freestyle: 'Middle of Nowhere' stirs imagination ? Honolulu, Hawaii ...

Sundance Film Festival award-winner 'Middle of Nowhere,' starring Emayatzi Corineadli, pictured, is coming to the Doris Duke Theatre. (Courtesy photo)

Sundance Film Festival award-winner "Middle of Nowhere," starring Emayatzi Corineadli, pictured, is coming to the Doris Duke Theatre. (Courtesy photo)

BY ELIZABETH KIESZKOWSKI / ekieszkowski@staradvertiser.com

Ava DuVernay?s ?Middle of Nowhere? is a significant film. DuVernay made history this year with her Best Director Award at the Sundance Film Festival, as the first black woman to take this prize. It?s an atmospheric, thoughtfully presented and beautifully acted independent movie, illuminating the experience of imprisonment ? actual and metaphorical.

In the film, a talented medical student puts her dreams on hold while her husband is in prison. The film considers the woman?s story up front, and we don?t know at first why the man is in jail. What we see is the depth of the wife?s passion, her steadfastness, the burden she bears in keeping contact with him and the sacrifices she makes.

With disproportionate numbers of African-American men imprisoned in the United States today, a film that brings to light the way this affects women?s lives is worth your time. But don?t be too comfortable in your expectations.

The movie doesn?t settle for making either the heroine (Emayatzi Corineadli) or her jailed husband (Omari Hardwick) one-dimensional victims. It takes off in less predictable directions, and the pensive Corineadli keeps your attention as she faces up to her situation. The handsome David Oyelowo also plays an instrumental part in this story.

Kenneth Turan of the Los Angeles Times calls it ?classic filmmaking of a completely different sort.? The New York Times called it ?soul-stirring.? And now the film is being bandied about as a possible Oscar contender in the Best Screenplay category.

The filmmaker?s own story is also inspiring. An accomplished publicist, she did not go to film school, but has said that she learned by observing on set with clients that included Steven Spielberg, Clint Eastwood and Michael Mann.

See the film at Honolulu Museum?s Doris Duke Theatre, with screenings tomorrow through Dec. 7. (Click here for showtimes and to buy tickets online.) It serves as a preview for the museum?s African American Film Festival, coming up in February.

I THINK you?ll like the music as well. DuVernay knows music: She?s the director of the 2008 hip hop documentary ?This is The Life,? and of 2010 BET/TV One docs ?My Mic Sounds Nice? ? on female hip hop artists ? and ?Essence Music Festival 2010.?

I went looking for the soundtrack artists, taken by the moody, sensual aura the movie?s music created ? most by women artists. They include the amazing Little Dragon and Goapele ? both have performed in Honolulu ? as well as other dreamy acts like MelodiousFly and Ra-Re Valverde (check out this hypnotic track, ?On Time?). I?ve been listening to this music all week!

I was especially drawn in by the mysterious post-punk/live electro of Spektrum, an outspoken British trio headed by singer Lola Olafisoye ? and was pleased to discover a Pacific connection, as Spektrum drummer Isaac Tucker is from New Zealand. The band is playing several shows in New Zealand this month, culminating with New Year?s Eve. Too bad I don?t have any vacation left! Let me share some of this awesomeness with you. Thank me later, leave a comment, or better yet, go forth and buy some of this gorgeous music.
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Elizabeth Kieszkowski is editor of TGIF, the Honolulu Star-Advertiser?s weekly arts and entertainment section. Reach her via email at ekieszkowski@staradvertiser.com or follow her on Twitter.

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Source: http://www.honolulupulse.com/reviews/freestyle-middle-of-nowhere-stirs-imagination

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'Killing Them Softly' delivers bullets and Brad Pitt

Melinda Sue Gordon / The Weinstein Company

Brad Pitt in "Killing Them Softly."

By Todd McCarthy, The Hollywood Reporter

REVIEW:?A juicy, bloody, grimy and profane crime drama that amply satisfies as a deep-dish genre piece, "Killing Them Softly" rather insistently also wants to be something more.

Writer-director Andrew Dominik, whose extraordinary Western "The Assassination of Jesse James by the Coward Robert Ford" proved too long and arty for the masses, repositions George V. Higgins? 1974 Boston mob-world novel as a metaphor for the ills of American capitalism circa 2008, a neatly provocative tactic. But he also shamelessly shows off his directorial acumen; unlike the leading character, who?s all business, Dominik makes sure you notice all his moves. Tight, absorbing and entertainingly performed by a virtually all-male cast topped by Brad Pitt, this Weinstein Co. release should generate solid mid-level business this fall.

PHOTOS: Cannes 2012: Competition lineup features "Cosmopolis," "Moonrise Kingdom," "Killing Them Softly"

A lawyer, professor and assistant U.S. Attorney who long investigated organized crime in addition to writing 27 novels, Higgins knew well of what he wrote. His first novel, "The Friends of Eddie Coyle," was made into a fine film and his third, "Cogan?s Trade," ?the basis of this one, consists of torrents of exceptionally vivid Beantown wiseguy dialogue with bits of plot tucked almost incidentally into the chatter.

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Moving the action to decimated post-Katrina New Orleans without a tourist in sight, Dominik has done a keen, disciplined job of coaxing the plot out of the shadows while retaining the flavor of underclass lingo and attitude. With the background dominated by then-presidential candidate Barack Obama?s optimistic speeches stressing the availability of ?the American promise? to all, some bottom-feeding criminals plot what looks like a no-risk scheme: Old-timer Johnny Amato (Vincent Curatola, the great Johnny Sack of "The Sopranos") hires unwashed kids Frankie (Scoot McNairy) and Russell (Ben Mendelsohn) to raid the regular card night run by Markie Trattman (Ray Liotta), who once robbed his own game and got away with it.

PHOTOS: Outtakes from Brad Pitt's THR cover shoot

While allowing these low-enders to emerge in all their miserable glory, Dominik also adds his own flourishes right from the outset, from striking lateral camera moves to amusingly supplying one of the young hoods with a pathetic little dog. Despite their general ineptitude, the boys pull off the job, but this is bad news for Markie, as it?s going to be assumed he?s run the same scam a second time.

At least this is what is suspected by the unnamed and unseen corporate mob, which has cog-in-the-system ?Driver? (Richard Jenkins) engage shrewd hit man Jackie Cogan (Pitt) to deal with this disruption of business as usual. Needlessly, Markie gets horribly beat up, Cogan brings in another hired killer, Mickey (James Gandolfini) to help him with a double-killing, and plenty more blood gets spilled before order is, after a fashion, restored.

Although the plot bases are dutifully, if briefly, covered, this is a crime story like so many others in which it doesn?t really matter if you can follow who everyone is and why awful things are happening to them; it?s basically a given that everyone on view is guilty of something, so you can?t feel too badly when they come to grisly ends.

PHOTOS: Cannes Film Festival: Veterans ready to return to the Croisette

What matter more are style and attitude, which Dominik ladles on like sauce on ribs. Russell?s drug-addled disorientation is represented by multiple distortions of time, visual perception and sound; the pursuit of one victim is imaginatively covered entirely from the outside of the building in which the chase is consummated; Cogan arrives on the scene to the accompaniment of Johnny Cash?s ?The Man Comes Around?; the just-scraping-by 21st century hoods drive late-?60s/early-?70s cars like a Riviera and Toronado; and one man?s execution is rendered from many angles in a slow-motion explosion of breaking glass and penetrating bullets so elaborate and prolonged that it resembles a self-standing art installation.

In a related way, some of the dialogue scenes, especially a couple of near-monologues superbly delivered by Gandolfini as a booze-guzzling, sex-obsessed, past-his-prime hit man, almost have the feel of brilliant, free-standing acting class scenes; they serve the film?s purposes, to be sure, but there?s a self-consciously showy aspect to them that makes you easily imagine students using them as audition pieces.

The film is terribly smart in every respect, with ne?er-a-false note performances and superb craft work from top to bottom, but it never lets you forget it, from Pitt?s pithy excoriation of Thomas Jefferson?s hypocrisy right down to his ?Crime is the business of America? final line that is bound to be widely quoted.?

The film noir crime dramas of the late 1940s and early 1950s were about a palpable unease in the country, but this remained a subtext rather than the overt subject of the films. Here, Dominik explicitly articulates his intended meanings, which have to do with money, institutional rot and what happens when you don?t keep your economic house in order. Either approach is valid but, perhaps in this day and age, audiences need their messages to be quick and direct. "Killing Them Softly" delivers them that way.

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Source: http://entertainment.nbcnews.com/_news/2012/11/27/15480178-killing-them-softly-delivers-bullets-and-brad-pitt-with-style-and-attitude?lite

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Thursday, 29 November 2012

Smart Fitness Trackers ? A Healthy, High-Tech Holiday Gift | Rock ...

One of the year?s most popular trends in digital health is the rise of smart fitness trackers. Going far beyond merely counting your steps, these devices connect you to a wide variety of online and offline health and fitness tools. They?re all reasonably stylish and affordably priced as well, so they?d make the http://rockhealth.com/2012/11/smart-fitness-trackers-a-healthy-high-tech-holiday-gift/perfect holiday gift.?

Currently on my wrist is the Nike+ Fuelband, which tracks your steps, calories burned, current time, and progress toward an activity goal on a LED-display. If you already own a Nike+ product, such as an iPod or a shoe sensor, the Fuelband will perfectly complement them.

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If you?re a fan of fitness-tracking wristbands, you might also be pleased to know that Jawbone has re-released it?s popular UP wristband. UP has re-engineered electronics that will reliably track your fitness activity and sleep. It has an amazing 10-day battery life as well.

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Lark, a company known for its sleep trackers, has also entered the fitness tracker market with its new Larklife fitness device. Designed by a team that includes a Stanford neuroeconomist, a sleep coach to professional athletes, a Harvard psychologist, and the team behind Beats by Dr. Dre, Larklife not only tracks your fitness activity, but also coaches you to build better habits.

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Fitbit also has a couple new fitness trackers which may appear small in size, but are big in features. ?The Fitbit Zip is a petite tracker (about the size of a quarter coin) that comes in five fun colors. At $60, it?s the least expensive tracker out there. The Fitbit One, which replaced the flagship Fitbit Ultra, tracks your steps, distance, and calories, but also tracks your sleep and gently wakes you up with a built-in vibrating alarm. Both Fitbit devices sync to your phone via Bluetooth and include access to a very robust suite of health and fitness tools.

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Finally, Misfit Wearables recently announced the Misfit Shine. The Shine is an attractive, all-metal, waterproof tracker that not only counts your steps, but your bike pedals and swim strokes as well. It syncs using a special technology that doesn?t involve cables, docking stations, or even wireless pairing. The Shine won?t be available until March, but you can head to Misfit Wearables? website to pre-order one for a friend (or yourself).

Source: http://rockhealth.com/2012/11/smart-fitness-trackers-a-healthy-high-tech-holiday-gift/

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Chromatin remodeling: Activating ACL1 with a little help from 'friends'

ScienceDaily (Nov. 29, 2012) ? Chromatin remodeling -- the packaging and unpackaging of genomic DNA and its associated proteins -- regulates a host of fundamental cellular processes including gene transcription, DNA repair, programmed cell death as well as cell fate. In their latest study, scientists at the Stowers Institute for Medical Research are continuing to unravel the finicky details of how these architectural alterations are controlled.

Through a series of biochemical experiments, Stowers Investigators Ron Conaway, Ph.D., and Joan Conaway, Ph.D., and their team discovered that chromatin remodeling enzyme and suspected oncogene ALC1 (short for Amplified in Liver Cancer 1) is activated through an unusual mechanism: Its shape shifts in the presence of its activators. Their finding identifies a new instrument in cells' molecular repertoire of chromatin-remodeling tools and a potential cancer therapeutic target.

One of the main tasks of chromatin remodeling enzymes, Ron Conaway explains, is "to make DNA accessible so events like repair and gene transcription can occur." Postdoctoral research associate and first author Aaron Gottschalk, Ph.D., previously figured out that ALC1 required protein partners to activate its remodeling function. Publishing in an upcoming issue of the Journal of Biological Chemistry, he dissects the mechanism by which this occurs.

ALC1 and its ilk have a common protein domain, SNF2, that uses the energy of ATP hydrolysis to move nucleosomes -- the basic repeating units of chromatin -- around, in a process called nucleosome sliding.

"I was intrigued because ALC1 has a unique macrodomain not found on any other SNF2 family member," Gottschalk says. His interest was further piqued when he found that while most ATP-dependent chromatin remodelers function as large multi-protein complexes, ALC1 appeared to work by itself. At the same time, where most of its group-happy family members readily demonstrated nucleosome sliding activity in vitro, ALC1 was not only a lone ranger but also "completely dead on its own."

Gottschalk deduced that ALC1 may function independently, but it needs a boost from a couple of sidekicks: PARP1, an enzyme that responds to several kinds of DNA damage; and NAD+, the substrate by which PARP1 transfers chains of poly (ADP-ribose) onto itself and other target proteins, in a process called PARylation.

Only when PARP1 and NAD+ are on the scene does ALC1 spring into action, altering the accessibility of DNA by shifting nucleosomes around. Gottschalk's earlier findings were published in the Proceedings of the National Academy of Sciences in June 2009.

"We then extended this research," Conaway says, "and the upshot of our recent JBC paper is that ALC1 is likely activated through a series of physical interactions. ALC1's unique macrodomain can bind PAR, and protein-protein interactions also occur between ALC1 and PARP1." Gottschalk and coauthor Rushi Trivedi, a graduate student in the Biochemistry & Molecular Biology department at KU Medical Center, developed a novel footprinting assay that enabled this observation. Rather than merely activating ALC1 and moving on, the researchers found that the trio of PARP1, NAD+ and ALC1 hangs out in a stable complex.

"So PARylated PARP1 and NAD+ are allosteric effectors -- by binding to ALC1, they alter its state from dormant to active," Conaway says. "It's an interesting mechanism that's different from how most other chromatin remodelers work. It may also help explain other evidence that PARP1 has the ability to rearrange nucleosomes and reorganize chromatin; this could be one way by which PARP1 exerts its influence."

Apart from its role in modifying chromatin structure, not much is currently known about ALC1. It's regarded as a possible oncogene, being found in excess in hepatocellular carcinoma cells and because overexpression of ALC1 in mice induces spontaneous tumors.

PARP1, on the other hand, has attracted plenty of interest as a potential anticancer drug target, due to its importance in maintaining genomic integrity. For example, in breast cancer cells lacking BRCA1 or BRCA2 function, blocking PARP could effectively remove the cells' last line of defense against DNA-damaging chemotherapy agents. To date, no PARP inhibitor has made it past phase III clinical trials, but pharmaceutical companies continue to chip away at the challenges around optimizing this form of targeted cancer therapy.

"A better understanding of the in-depth biochemistry we're uncovering on ALC1 and PARP1 may, in the long term, ultimately lead to new or more refined therapeutic strategies," Gottschalk says.

Meanwhile, having observed that ALC1 comes to life upon interacting with friends, Gottschalk now wants to understand precisely how this activation happens. With a knockout ALC1 mouse model handy, plans are afoot to extend his studies to an in vivo characterization of a chromatin remodeler that boasts an illustrious family pedigree, yet stands apart in the crowd.

Funding for this study came from a National Institute of General Medical Sciences grant (GM41628), and a grant to the Stowers Institute from the Helen Nelson Medical Research Fund at the Greater Kansas City Community Foundation.

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Story Source:

The above story is reprinted from materials provided by Stowers Institute for Medical Research.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. A. J. Gottschalk, R. D. Trivedi, J. W. Conaway, R. C. Conaway. Activation of the SNF2 Family ATPase ALC1 by Poly(ADP-ribose) in a Stable Nucleosome-PARP1-ALC1 Intermediate. Journal of Biological Chemistry, 2012; DOI: 10.1074/jbc.M112.401141

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/miSQ5ef0V9Y/121129151918.htm

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Mortgage Debt at Lowest Level Since 2006, Despite Increase in Originations

Despite a sizeable increase in consumer debt overall household debt fell by $74 billion in the third quarter of 2012, driven largely by a decrease in mortgage and home equity loan balances. The Federal Reserve Bank of New York's Quarterly Report on Household Debt and Credit reported that a drop of $120 billion in mortgage debt and $16 billion in home equity lines of credit were partially offset by a 2.3 percent increase in non-real estate obligations.

The drop in aggregate consumer debt continued a near-four year downward trend.? At of the end of the quarter (September 30) total consumer indebtedness was $11.31 trillion, 0.7 percent lower than in the second quarter and $1.37 trillion less than the peak household debt hit in the third quarter of 2008.

Mortgage debt, the largest component of the aggregate, now stands at $8.03 trillion, down 1.5 percent from the previous quarter and the lowest level since 2006.? The decline has come in spite of the fourth consecutive increase in mortgage originations with $521 billion in new mortgage debt appearing on consumer credit reports.?

The other major components of debt increased.? Student loan debt increased by $42 billion to $956 billion.? The Federal Reserve reports, however, that of the $42 billion only $23 billion is new debt while the remaining $19 billion is attributed to previously defaulted student loans that have been updated on credit reports this quarter, increasing the 90+ day delinquency rate for student loans to 11 percent.

Outstanding balances on auto loans increased by $18 billion to $768 billion, the highest level in nearly four years and the sixth quarter this debt has increased.? Originations increased by 4.4 percent to $85.8 billion, the third consecutive quarterly increase.????????

Credit card balances were up $2 billion while aggregate credit card limits were down 0.3 percent or $9 billion during the quarter.? There are 382 million open credit card accounts, down slightly from the second quarter, while the number of credit inquiries decreased by one million to 167 million over a rolling six month period.

"The increase in mortgage originations, auto loans and credit card balances suggests that consumers are slowly gaining confidence in their financial position," said Donghoon Lee, senior economist at the New York Fed. "As consumers feel more comfortable, they may start to make purchases that were previously delayed."

Overall, delinquency rates improved slightly in the third quarter to 8.9 percent of outstanding debt compared to 9.0 percent in the second quarter.? This equates to about $1.01 trillion of delinquent debt, approximately $740 billion of which is seriously delinquent, i.e. 90+ days past due.

The percentage of auto loan debt that is seriously delinquent was unchanged at 4.2 percent while student loan debt, as noted above, rose to 11 percent.? Delinquency rates for mortgages decreased from 6.3 percent to 5.9 percent and new foreclosures are returning to their pre-crisis levels with new foreclosure notices added to 242,000 consumer credit reports. This was the lowest number in nearly six years.? Home equity lines of credit delinquencies remain high by historical standards at 4.9 percent.

Delinquency transition rates for current mortgage accounts were roughly unchanged, with 1.9% of current mortgage balances transitioning into delinquency. However, the rate of transition from early (30-60 days) into serious (90 days or? more) delinquency increased to 26.3%, up by 2.8 percentage points from the second quarter. ?Furthermore, the cure rate - the share of balances that transitioned from 30-60 days delinquent to current - saw a second consecutive decline to 26.4%.

About 354,000 consumers had a bankruptcy notation added to their credit reports in 2012Q3, a 16.3% drop from the same quarter last year, and the seventh consecutive drop in bankruptcies on a year-over-year basis.

Source: http://www.mortgagenewsdaily.com/11282012_consumer_debt.asp

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Wednesday, 28 November 2012

Nine radar images of asteroid 2007 PA8

ScienceDaily (Nov. 27, 2012) ? A collage shows nine radar images of near-Earth asteroid 2007 PA8 that were obtained between Oct. 31 and Nov. 13, 2012, with data collected by NASA's 230-foot-wide (70-meter) Deep Space Network antenna at Goldstone, Calif. On Nov. 5 at 8:42 a.m. PST (11:42 a.m. EST/16:42 UTC), the object came about 4 million miles (6.5 million kilometers) from Earth, or 17 times the distance between Earth and the moon.

The images of 2007 PA8 reveal possible craters, boulders, an irregular, asymmetric shape, and very slow rotation. The asteroid measures approximately one mile wide (about 1.6 kilometers).

Each panel shows one image per day, and all of them are oriented so rotation is counterclockwise. Each image is shown at the same scale and covers 1.1 miles (1.7 kilometers) from top to bottom. The resolution of the images varies from day to day as the asteroid's distance changed. The images achieve resolutions as fine as 12 feet (3.75 meters) per pixel on Nov. 5 and 6, when the asteroid was closest. The resolution was 25 feet (7.5 meters) per pixel on Nov. 2, 3 and 8, and 62 feet (18.75 meters) per pixel on Oct. 31 and Nov. 11 to 13.

New radar measurements of 2007 PA8's distance and line-of-sight velocity refined calculations of its orbit about the sun, enabling reliable computation of the asteroid's motion for the next 632 years. 2007 PA8 is not a threat to Earth. The 2012 flyby was the closest since 1880. The next flyby with Earth closer than the one that occurred this year will be in 2488, when the asteroid will approach no closer than 3.6 million miles (5.8 million kilometers).

NASA detects, tracks and characterizes asteroids and comets passing close to Earth using both ground- and space-based telescopes. The Near-Earth Object Observations Program, commonly called "Spaceguard," discovers these objects, characterizes a subset of them, and plots their orbits to determine if any could be potentially hazardous to our planet.

JPL manages the Near-Earth Object Program Office for NASA's Science Mission Directorate in Washington. JPL is a division of the California Institute of Technology in Pasadena.

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The above story is reprinted from materials provided by NASA/Jet Propulsion Laboratory.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://www.sciencedaily.com/releases/2012/11/121127145950.htm

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In Egypt and Tunisia, Salafis move from prisons to parliaments

Mehdi Mezmi rediscovered Islam eight years ago via a website, then illegal to access in his native Tunisia, called Minbar at-Tawheed wal Jihad ? ?The Forum for God?s Oneness and Holy Struggle.?

It seemed to him a dark time for Islam. Afghanistan and Iraq were under US assault. At home, President Zine El Abidine Ben Ali was jailing the pious under a new anti-terrorism law. Mr. Mezmi read about the struggles of the early Muslims, and was inspired.

?I felt the prophet was talking about our times and what was happening in the world,? he says.

Today Mezmi works as a tugboat engineer in Tunis. He?s also part of a deeply conservative ? and sometimes violent - Islamic current known as Salafism that has gathered force in North Africa since the 2011 uprisings. It's inevitable that Salafis will help guide their countries? evolution. The challenge for governments is to make sure they do so peacefully.

Sunni and Shiite Islam: Do you know the difference? Take our quiz.

Salafis made international headlines in September with assaults on US embassies in Libya, Tunisia, and Egypt. While they have mainly acted as pressure groups so far, some leaders fearful of violence want to steer Salafi activists into politics instead.

?There must be zero tolerance toward violence,? says Said Ferjani, a political bureau member of Ennahda, the moderate Islamist party that leads Tunisia?s coalition government. ?We have to bring them into the sphere of intellectual and theological debate, because where there is debate, you can challenge their views.?

REVERSION TO 'EARLY ISLAM'

Salafis are Sunni Muslims who aim to emulate Islam?s first three generations, called ?salaf? in Arabic, in a quest to transform society. But views differ on the right approach. Many Salafis simply try to set an example. Some get involved in preaching and charity work. A minority embrace varying degrees of violence.

The evolution of Salafi thinking dates to medieval scholars such as Ibn Taymiyyah. His call to scrap centuries of jurisprudence and return to the ?pure? Islam of the prophet Mohammed's time has inspired generations of fundamentalist reformers.

One was the 18th century scholar Mohammed Ibn Abdel Wahhab, who branded other Muslims infidels ? a widely reviled practice called takfir ? and teamed up with the Al Saud family to seize control of central Arabia. His teachings now form the basis of Saudi Arabia?s state creed.

Most Salafi scholars, however, have warned against getting into politics. Sometimes called Scholastic Salafism, this school of thought urges Muslims to live piously and invite others to do likewise.

Both Salafis and more moderate reformers have long debated issues such as takfir, the concept of holy struggle called jihad, and the role of sharia ? the comprehensive understanding of how Islam guides life. In recent decades a new discourse has offered stark answers.

Forged in the crucible of the 1980s Afghan war, the violent fundamentalism of Al Qaeda and its cheerleaders demands direct application of sharia, depicts Islam as under attack ? including by some Muslim-world governments ? and calls on Muslims to fight in its defense. Those who do so are often called Salafi jihadis.

MAKING SENSE OF LIFE

Meanwhile in North Africa, the regimes of Tunisia?s Ben Ali, Libya?s Muammar Qaddafi, and Egypt?s Hosni Mubarak spent decades trampling dissent, letting unemployment skyrocket, and seeking to varying degrees to control religious life.

For some North Africans raised in the bleak landscape of authoritarianism, Islamic activism offers meaning, says Isabelle Werenfels, a specialist on the Middle East and Africa at the German Institute for International and Security Affairs, in Berlin.

?Many of the people termed Salafi don?t really know much about Islam,? she says. ?These are young people who don?t have many choices. They?re looking for a way to give sense to life.?

Sunni and Shiite Islam: Do you know the difference? Take our quiz.

Mezmi has studied Islam for longer than many young Salafis, but he waited five years before he dared let his beard grow ? a good way to attract the police in Ben Ali?s Tunisia. His friend Hamza El Arabi, an engineer at a plastics factory, also studied discreetly. The two men grew up in El Kram, a working-class neighborhood of Tunis. One recent evening they were sharing an outdoor caf? table with their friend Redouan, also a Salafi. Inside, dozens of eyes were glued to a soccer match on TV.

?Before, it was like I didn?t have an identity,? says Redouan, 26, who began studying Islam in 2010. In jeans and sneakers, he and his friends still look like most of the other young men at the caf? ? save for their beards. ?I was drinking and playing cards. And in Islam I found my identity.?

A SLIDE TOWARD INTOLERANCE

Since last year, a growing number of North Africans ? mainly young men ? has translated that sense of identity into action. Most Salafi activism has been peaceful. But violence has risen, from messy scraps between police and rioters to religiously-driven vandalism.

In Tunisia, Salafis have done charitable work and called for religious freedoms ? such as lifting restrictions on Islamic dress ? denied them under Ben Ali. But some have also lashed out at what they call blasphemy.

Demonstrations last year against a Tunis TV station that aired the film ?Persepolis,? which contains an image of God, ended in rioting. Last June Salafi activists trashed an art show on similar grounds, with similar results.

In Libya, Islamic hardliners have wrecked several mosques associated with Islam?s mystical Sufi traditions. Sufis often congregate around spiritual leaders they believe transmit God?s blessing, and bury them inside mosques. To Salafis, that can look like witchcraft and polytheism.

?If these people controlled the country they?d kill everyone,? says Abdelbaset al Turki, a relative of Sheikh Abderrahman al Turki, who since 2003 has led the Sufi community at the Zaouia al Shaab mosque overlooking Tripoli?s harbor.

One morning in August, Abdelbaset al Turki watched Salafis bulldoze the Zaouia, pick-axe open graves, and pull out four bodies including Sheikh Abderrahman?s father and grandfather. Nominally pro-government militiaman on gun-mounted pick-ups blocked any interference.

Now the Zaouia al Shaab Sufis frequent the home of Sheikh Abderrahman, a converted garage, where one September afternoon Abdelbaset al Turki and his brother, Fathi, were having tea. Photos of robed figures hung on the wall. The men say rigid Salafi doctrines contradict Islam.

?Sufis know the history of Ibn Abdel Wahhab and the Wahhabi discord, and stay with the true belief,? says Fathi al Turki.

Just weeks after the Zaouia al Shaab was destroyed, four US diplomats were killed in an assault on the US consulate in Benghazi that US officials blame on a local Salafi Jihadi militia with possible links to Al Qaeda. Three days later, Salafi-led mobs attacked US embassies in Cairo and Tunis over an American-made film that lampooned the prophet Mohammed.

Mezmi and his friends blame such excess in part on a shaky grasp of religion. Several Salafi-led demonstrations in Tunisia have turned violent after hordes of young men ? some perhaps Salafis, some apparently just poor and angry ? seized the occasion to brawl with police.

?If Abou Iyadh calls for a demonstration, thousands of Salafis will turn out,? Mezmi says, citing a prominent Tunisian Salafi. ?But so will thousands of other guys, because they?re Muslims, and some of them are ignorant and throw stones.?

Sunni and Shiite Islam: Do you know the difference? Take our quiz.

The solution, they say, is better knowledge of Islam.

?We have sheikhs in Tunisia and abroad, like in Saudi prisons and in Yemen,? says El Arabi. ?Their teachings are available online.?

WORKING WITHIN THE SYSTEM

However, that sort of ad-hoc study invites extremist ideas, says Mr. Ferjani, from Ennahda. His party wants to tackle job-creation while also training mainstream religious teachers to coax Salafis from society?s margins into political life.

In Egypt, that has already begun. Salafis generally stayed out of politics under Mr. Mubarak?s rule. Some objected on religious grounds to any semblance of democracy, however flawed. Others preferred to sit out a rigged game. But recently some have changed tack.

The Salafi Nour Party won nearly a quarter of seats in Egypt?s lower house of parliament, which has since been dissolved, in elections last year. It sees politics as a way ?to express our own point of view, to have pressure power, and to participate in the next government,? says spokesman Nader Bakkar.

The Nour Party wants to put its stamp on Egypt?s new constitution. It strove to make a more direct connection to sharia via an article making the ?principles of sharia? the main source of legislation and pushed hard ? if unsuccessfully ? for Cairo?s Al Azhar University, a leading Islamic authority, to vet laws for sharia compliance.

The prospect of Salafis in politics has gotten mixed reviews. While some Egyptians prefer them to the slick businessmen who rose to power under Mubarak, others worry of a clampdown on personal freedoms. As a Cairo taxi driver named Hossam put it, ?they?ll make us stop listening to music and grow our beards.

In Tunisia, a leaked video in October showing Ennahda?s leader, Rached Ghannouchi, advising Salafis to work gradually, prompted liberals to cry conspiracy. Ennahda said the remarks, recorded last April, were taken out of context.

?Politics could bring an element of realism to [Salafis?] perceptions and approaches,? argues Ferjani. ?They must make an adjustment, and that can only happen within the sphere of democratic interaction.?

DEMOCRACY VS. ISLAM?

In Tunisia, the newly-minted Reform Party hopes to play that role, says its president, Mohamed Khoja. Two decades ago his activity in underground Islamist circles earned him ten months in Ben Ali?s jails. Today his party wants to channel resurgent Salafi energy into politics.

?It?s not a choice between democracy and Islam,? he says. ?The people can have political authority ? what matters is that governance is Islamic and law adheres to sharia.?

For now, Mr. Khoja and his party are trying to win the ear of young Salafis. Winning their support may prove difficult. Many reject democracy as un-Islamic.

??God?s governance but the people?s authority? ? that?s just philosophizing,? says Mezmi, using a term that in Islamic parlance often equates to ?splitting hairs.?

He and his friends want to refashion society, but through other means than electoral politics.

?Governance should be what comes to us from God,? says El Arabi. ?Not communism, not liberalism, not secularism. Only Islam.?

Read this story at csmonitor.com

Become a part of the Monitor community

Source: http://news.yahoo.com/egypt-tunisia-salafis-move-prisons-parliaments-161256728.html

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Merkel's election schedule weighs on Greek bailout

FILE - In this Oct. 9, 2012 file picture Greece's Prime Minister Antonis Samaras, right, and Germany's Chancellor Angela Merkel speak after their statements to the media at the Maximos mansion in Athens. German Chancellor Angela Merkel's upcoming re-election battle is shaping Europe's response to bailing out debt-ridden Greece.The strategy: do just enough to keep Greece afloat but spare German voters _ for now _ the news that their money will be required to get the Greeks back on their feet. The deal reached Tuesday by the 17 nations that use the euro is a patchwork of measures to plug new shortfalls in Greece's budget and trim its debt load over the coming years. But it stopped short of forgiving some of the country's debt held by its eurozone creditors _ known euphemistically as a so-called haircut. (AP Photo/Thanassis Stavrakis, Pool, File)

FILE - In this Oct. 9, 2012 file picture Greece's Prime Minister Antonis Samaras, right, and Germany's Chancellor Angela Merkel speak after their statements to the media at the Maximos mansion in Athens. German Chancellor Angela Merkel's upcoming re-election battle is shaping Europe's response to bailing out debt-ridden Greece.The strategy: do just enough to keep Greece afloat but spare German voters _ for now _ the news that their money will be required to get the Greeks back on their feet. The deal reached Tuesday by the 17 nations that use the euro is a patchwork of measures to plug new shortfalls in Greece's budget and trim its debt load over the coming years. But it stopped short of forgiving some of the country's debt held by its eurozone creditors _ known euphemistically as a so-called haircut. (AP Photo/Thanassis Stavrakis, Pool, File)

German Chancellor Angela Merkel carries files as she arrives for the weekly cabinet meeting at the chancellery in Berlin, Germany, Wednesday, Nov. 28, 2012. (AP Photo/Michael Sohn)

German chancellor Angela Merkel smiles as she is illuminated by a beamer as she arrives for a ceremony of the association of welfare organizations BAGFW in Berlin, Tuesday, Nov. 27, 2012. (AP Photo/Johannes Eisele, pool)

German Chancellor Angela Merkel smiles as she arrives for the weekly cabinet meeting at the chancellery in Berlin, Germany, Wednesday, Nov. 28, 2012. (AP Photo/Michael Sohn)

German Chancellor Angela Merkel smiles as she arrives for the weekly cabinet meeting at the chancellery in Berlin, Germany, Wednesday, Nov. 28, 2012. (AP Photo/Michael Sohn)

(AP) ? German Chancellor Angela Merkel's upcoming re-election battle is shaping Europe's response to bailing out debt-ridden Greece.

Her strategy: Do just enough to keep Greece afloat but spare German voters ? for now ? the news that even more of their money will be required to get the Greeks back on their feet.

Merkel has led Europe's biggest economy since 2005. The greatest risk to her re-election bid, pollsters and analysts say, is a dramatic worsening of Europe's debt crisis ? such as Greece exiting the eurozone, or a Greek debt write-off costing billions in German taxpayer money.

A deal reached Tuesday by the 17 nations that use the euro is a patchwork of measures to plug new shortfalls in Greece's budget and trim its debt load over the coming years. But it stopped short of forgiving some of the country's debt ? having eurozone creditors like Germany take a so-called "haircut."

"Greece's debt is not sustainable, even with the new measures, so the problem will be back in 2014 at the latest," said Christoph Weil, an economist with Commerzbank.

But losing more money on rescuing the Greeks and other economically weak European Union nations could be politically toxic in Germany, where Merkel faces a national election in September. So far, Merkel's hard-nosed approach to Europe's debt crisis has bolstered her popularity at home.

"Ms. Merkel doesn't want to stand in front of her voters and tell them that the Greek rescue will cost taxpayers a couple of billions," Weil added.

Many economists say that Greece's debt burden ? forecast to reach some 190 percent of gross domestic product next year ? can only be managed by writing off more government loans. But Merkel and German Finance Minister Wolfgang Schaeuble were the most outspoken opponents of such a step, instead insisting on austerity measures and structural reforms.

"A haircut is urgently necessary. This constant strategy of muddling through instead of tackling the problem won't work in the long run," Weil said.

Greece is currently heading into its sixth consecutive year of a deep recession with unemployment hovering around 25 percent.

Tuesday's deal forecasts that Greece's debt will shrink to 124 percent in 2020 and "sustainably less" than 110 percent only two years later. Many private economists call those projections wishful thinking, saying they are based on overly optimistic budget and growth assumptions ? especially with the overall eurozone now in recession.

Recent German public opinion surveys consistently show Merkel's conservative bloc as the country's strongest party, though her junior coalition partners, the pro-business Free Democrats, are struggling, possibly jeopardizing her ability to form a new coalition government.

Neither Merkel's coalition nor the two main opposition parties are currently seen as winning a clear majority to form a government.

Analysts have estimated that a full-fledged haircut on Greek rescue loans could cost Germany, the main contributor to the bailouts, up to ?17 billion ($22 billion) ? more than 5 percent of Berlin's annual budget.

The mass-circulation daily Bild, never a fan of bailing out Athens, asked in a headline Wednesday: "Will this never stop? Yet more billions for Greece."

"I say that a haircut hasn't been avoided ? it has been delayed until a time after the parliamentary election," said Frank-Walter Steinmeier, a leader of the main opposition Social Democrats.

He says Merkel's government was concealing the truth for fear of being punished at the polls. Other German lawmakers agreed.

"One must get the impression that the German voting schedule was more important here than the basics of math," said Priska Hinz of the opposition Greens party. "It remains unclear how Greece can return to financial markets and how that is to be financed."

In rejecting of a debt write-off, the government "shies away from telling its people the truth and clearly say that keeping Greece in the eurozone does not only make sense but will also have a cost," she added.

Still, Germany's opposition is expected to join the government in approving the Tuesday deal to make sure Greece doesn't go bankrupt and abandon the euro. Parliament is expected to vote on Friday.

For his part, Schaeuble rejected the claims that Germany's response to the Greek crisis was being driven by the election calendar. Instead, he defended the Tuesday deal, saying it leaves no doubt that Greece must first implement austerity measures and structural reforms for the bailout to work.

But Schaeuble acknowledged that the new measures for Greece not only consist of loans but might cost Germany up to ?730 million ($950 million) next year alone.

Ulrich Kater, the chief economist of Germany's DekaBank, said it was understandable that the German government didn't want to make far-reaching decisions ahead of an election.

"That shows how difficult it is to manage the eurozone, with its 17 nations where there's always an election looming somewhere," he said.

___

Juergen Baetz can be reached on Twitter at http://www.twitter.com/jbaetz

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2012-11-28-Germany-Merkel's%20Gamble/id-c020d97eec514020ba2c019df3fb15b6

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Tuesday, 27 November 2012

Five reasons America won't fall off the 'fiscal cliff'

The political and economic ramifications are too big for Washington to let the large tax increases and spending cuts take effect. But this doesn't necessarily mean lawmakers will craft a decisive solution to the nation's fiscal woes.

By David Grant,?Staff writer / November 25, 2012

This is the cover story from the Nov. 26 edition of The Christian Science MonitorWeekly.

Zina Saunders illustration

Enlarge

Relax, America. You can put your parachutes away. Washington isn't likely to take the country over the dreaded "fiscal cliff." Even a capital city as deadlocked and dysfunctional as Washington has been in recent years is not likely to risk a move that has so many economic and political ramifications, according to a wide range of experts.

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That is not to say the journey won't be contentious and perhaps a cliffhanger. Don't forget, the same cast of characters is starring in this big-screen epic ? either a dark comedy or a thriller, take your pick ? that has brought Americans to this point before: Democrats ruling the White House and Senate, and Republicans, including a clique of unyielding conservatives, in power in the House.

Yet analysts on both sides of the aisle believe that doing nothing, which on Jan. 1 would trigger the beginning of $600 billion in tax increases and large cuts to the federal budget, would inflict too much damage on individuals' wallets, on the economy, and on America's standing in the world.

The fiscal cliff, after all, was never intended to be a serious option. The elements of it grew out of years of debt avoidance and budget gimmickry that finally peaked in 2011 with the impasse over raising the federal debt ceiling. After a bipartisan congressional panel failed to agree on spending cuts, Republicans and Democrats added the infamous "sequestration" portion ? a series of automatic spending cuts that were so distasteful that lawmakers would be forced to agree on more sensible trims.

While an agreement to avoid the cliff could still prove elusive, many veteran Washington-watchers believe a compromise will be worked out to avoid plunging into the abyss on New Year's Eve.

"America's reputation and its economic stability are threatened dramatically by inaction," says Dan Glickman, a senior fellow at the Bipartisan Policy Center who previously served as President Clinton's secretary of Agriculture. "Except for a few zealots, most people aren't going to want to see that happen."

Some even believe that the looming fiscal cliff will eventually lead to a grand bargain between the White House and Capitol Hill on reforming America's tax code and entitlement programs ? setting the tone, perhaps, for other agreements over the next few years on issues from immigration to energy. But let's not get ahead of ourselves. Here are five reasons America won't ? or let's say shouldn't ? plunge off the fiscal cliff on Jan. 1.

Because of the "R" word.

Many believe the specter of a double-dip recession remains the most important reason that Congress and the president will reach some sort of accommodation by Jan. 1. It's something that neither party wants to see ? or be blamed for.

The Congressional Budget Office estimates that with the massive spending cuts and tax increases imposed by the cliff, US gross domestic product would shrink by a half percentage point in 2013. (Some private sector forecasters believe the hit could be even more severe.) That amounts to 2.7 million fewer jobs than the economy would otherwise create by year's end, the CBO says, which would push the unemployment rate, now at 7.9 percent, above 9 percent.

1?|?2?|?3?|?4?|?5

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/E6JdO1QLCzA/Five-reasons-America-won-t-fall-off-the-fiscal-cliff

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Kentucky study finds common drug increases deaths in atrial fibrillation patients

Kentucky study finds common drug increases deaths in atrial fibrillation patients [ Back to EurekAlert! ] Public release date: 27-Nov-2012
[ | E-mail | Share Share ]

Contact: Jodi Whitaker
jodi.whitaker@uky.edu
859-257-5307
University of Kentucky

LEXINGTON, Ky. (Nov. 27, 2012) -- Digoxin, a drug widely used to treat heart disease, increases the possibility of death when used by patients with a common heart rhythm problem ? atrial fibrillation (AF), according to new study findings by University of Kentucky researchers. The results have been published in the prestigious European Heart Journal, and raises serious concerns about the expansive use of this long-standing heart medication in patients with AF.

UK researchers led by Dr. Samy Claude Elayi, associate professor of medicine at UK HealthCare's Gill Heart Institute, analyzed data from 4,060 AF patients enrolled in the landmark Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) trial. This analysis was intended to determine the relationship between digoxin and deaths in this group of patients with atrial fibrillation, and whether digoxin was directly responsible for some deaths.

"These findings raise important concerns about the safety of digoxin, one of the oldest and most controversial heart drugs," said Dr. Steven E. Nissen, chair of cardiovascular medicine at the Cleveland Clinic. "Although considered obsolete by some authorities, digoxin is still widely used. A thorough review by the FDA is warranted to determine whether regulatory action is needed, including stronger warnings about the use of digoxin in patients with atrial fibrillation. "

Digoxin is extracted from the foxglove plant and it helps the heart beat more strongly, and at a slower heart rate. It is commonly used in AF patients and in patients with heart failure. However, it can be problematic to use successfully as there is a narrow dose range at which it is effective, and beyond which it can be dangerous.

Though digoxin has been used by physicians treating AF for decades, until now, there has been limited evidence demonstrating the effect of digoxin in patients with this condition. "Digoxin in AF patients has hardly been studied," said Elayi. "The main prospective randomised controlled trials available with digoxin were performed in patients with heart failure and sinus rhythm, and routinely excluded AF patients."

The results of the analysis found that digoxin was associated with a 41 percent increase in deaths from any cause after controlling for other medications and risk factors. An increase in deaths occurred regardless of gender or the presence or absence of underlying heart failure. Digoxin was also associated with a 35 percent increase in deaths from cardiovascular causes, and a 61 percent increase in deaths from arrhythmias or problems with the rate or rhythm of the heartbeat.

"Within five years of use, one additional AF patient out of six taking digoxin ? compared to those not on digoxin in the AFFIRM trial? will die from any cause," Elayi said. "One additional patient out of eight will die from cardiovascular causes, and one additional patient out of 16 will die from arrhythmias.

"This study calls into question the widespread use of digoxin in patients with AF, particularly when used for controlling AF rate in a similar way as in the AFFIRM trial," Elayi said. "These findings suggest that physicians should try to control a patient's heart rate by using alternatives such as beta-blockers or calcium blockers ,as a first line treatment.

"If digoxin is used, prescribers should use a low dose with careful clinical follow up, evaluate potential drug interactions when starting new medications, and monitor digoxin levels."

In addition, patients should also be aware of potential toxicity and see their physicians immediately in specific clinical situations, he said. For instance, if they experience increasing nausea, vomiting, palpitations or syncope, as those may precede arrhythmic death, Elayi added.

The researchers say that the mechanism by which digoxin increases deaths among patients is unclear. Deaths from classic cardiovascular causes - whether or not they are due to arrhythmia - can partly but not entirely explain it. This suggests there must be some additional mechanism that remains to be identified, said Elayi.

"Our study underscores the importance of reassessing the role of digoxin in the contemporary management of AF in patients with or without HF," concluded the authors in their paper. "There is a need for further studies of the drug's use, particularly in systolic heart failure patients and AF patients that would, in theory, benefit the most from digoxin."

###

Media Contact: Jodi Whitaker at (859) 257-5307


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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Kentucky study finds common drug increases deaths in atrial fibrillation patients [ Back to EurekAlert! ] Public release date: 27-Nov-2012
[ | E-mail | Share Share ]

Contact: Jodi Whitaker
jodi.whitaker@uky.edu
859-257-5307
University of Kentucky

LEXINGTON, Ky. (Nov. 27, 2012) -- Digoxin, a drug widely used to treat heart disease, increases the possibility of death when used by patients with a common heart rhythm problem ? atrial fibrillation (AF), according to new study findings by University of Kentucky researchers. The results have been published in the prestigious European Heart Journal, and raises serious concerns about the expansive use of this long-standing heart medication in patients with AF.

UK researchers led by Dr. Samy Claude Elayi, associate professor of medicine at UK HealthCare's Gill Heart Institute, analyzed data from 4,060 AF patients enrolled in the landmark Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) trial. This analysis was intended to determine the relationship between digoxin and deaths in this group of patients with atrial fibrillation, and whether digoxin was directly responsible for some deaths.

"These findings raise important concerns about the safety of digoxin, one of the oldest and most controversial heart drugs," said Dr. Steven E. Nissen, chair of cardiovascular medicine at the Cleveland Clinic. "Although considered obsolete by some authorities, digoxin is still widely used. A thorough review by the FDA is warranted to determine whether regulatory action is needed, including stronger warnings about the use of digoxin in patients with atrial fibrillation. "

Digoxin is extracted from the foxglove plant and it helps the heart beat more strongly, and at a slower heart rate. It is commonly used in AF patients and in patients with heart failure. However, it can be problematic to use successfully as there is a narrow dose range at which it is effective, and beyond which it can be dangerous.

Though digoxin has been used by physicians treating AF for decades, until now, there has been limited evidence demonstrating the effect of digoxin in patients with this condition. "Digoxin in AF patients has hardly been studied," said Elayi. "The main prospective randomised controlled trials available with digoxin were performed in patients with heart failure and sinus rhythm, and routinely excluded AF patients."

The results of the analysis found that digoxin was associated with a 41 percent increase in deaths from any cause after controlling for other medications and risk factors. An increase in deaths occurred regardless of gender or the presence or absence of underlying heart failure. Digoxin was also associated with a 35 percent increase in deaths from cardiovascular causes, and a 61 percent increase in deaths from arrhythmias or problems with the rate or rhythm of the heartbeat.

"Within five years of use, one additional AF patient out of six taking digoxin ? compared to those not on digoxin in the AFFIRM trial? will die from any cause," Elayi said. "One additional patient out of eight will die from cardiovascular causes, and one additional patient out of 16 will die from arrhythmias.

"This study calls into question the widespread use of digoxin in patients with AF, particularly when used for controlling AF rate in a similar way as in the AFFIRM trial," Elayi said. "These findings suggest that physicians should try to control a patient's heart rate by using alternatives such as beta-blockers or calcium blockers ,as a first line treatment.

"If digoxin is used, prescribers should use a low dose with careful clinical follow up, evaluate potential drug interactions when starting new medications, and monitor digoxin levels."

In addition, patients should also be aware of potential toxicity and see their physicians immediately in specific clinical situations, he said. For instance, if they experience increasing nausea, vomiting, palpitations or syncope, as those may precede arrhythmic death, Elayi added.

The researchers say that the mechanism by which digoxin increases deaths among patients is unclear. Deaths from classic cardiovascular causes - whether or not they are due to arrhythmia - can partly but not entirely explain it. This suggests there must be some additional mechanism that remains to be identified, said Elayi.

"Our study underscores the importance of reassessing the role of digoxin in the contemporary management of AF in patients with or without HF," concluded the authors in their paper. "There is a need for further studies of the drug's use, particularly in systolic heart failure patients and AF patients that would, in theory, benefit the most from digoxin."

###

Media Contact: Jodi Whitaker at (859) 257-5307


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2012-11/uok-ksf112712.php

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Shrubs lend an insight into a glacier's past

Shrubs lend an insight into a glacier's past [ Back to EurekAlert! ] Public release date: 26-Nov-2012
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Contact: Michael Bishop
michael.bishop@iop.org
01-179-301-032
Institute of Physics

The stems of shrubs have given researchers a window into a glacier's past, potentially allowing them to more accurately assess how they're set to change in the future.

Their findings have been published today, 27 November, in IOP Publishing's journal Environmental Research Letters, and show how a glacier's history of melting can be extended way past the instrumental record.

Much like the rings on a tree stump indicate how old it is, measuring the width of rings on the stem of a shrub can give a good indication of how well it has grown year on year. Under extreme environmental conditions, such as those close to a glacier, a shrub's growth relies heavily on summer temperatures, meaning the ring-width of a shrub can be used a proxy for glacial melting, which also relies heavily on summer temperatures.

Lead author of the study, Allan Buras, said: "In warm summers, shrubs grow more compared to cold summers. In contrast, a glacier's summer mass balance is more negative in warm summers, meaning there is more melting compared to cold summers.

"Big rings in shrubs therefore indicate comparably warm summers, and thus a strongly negative summer mass balance in other words, more melting."

The researchers, from the University of Greifswald, tested this theory on a local icecap in the Scandic Mountains of southern Norway. They took 24 samples of shrubs from a site close to the glacier and analysed their ring-widths.

Monthly precipitation and temperature data from a local climate station were retrieved from the Norwegian Meteorological Office, and the summer mass balance of the glacier, from 1963 to 2010, was retrieved from the existing literature.

Each of these data sets was then statistically tested to see if there was a correlation between them. The results showed a robust and reliable correlation between the ring-width of shrubs and the summer melting of the glacier.

"Our results show that it is possible to reconstruct glacier summer mass balance with shrub ring-width series and it is therefore theoretically possible to extent records of summer mass balance into the past," Buras continued.

The shrubs that were collected in the study were relatively young, only allowing for reliable reconstructions over the past 36 years, meaning they could not be used to extend the record of the glacier; however, the researchers are confident that this could have been achieved if longer-lived shrubs were selected.

Most of the available data on the mass balance of glaciers only spans several decades and there is some data missing, mainly because most glaciers are situated in hard-to-reach arctic and alpine areas.

With the possibility to extend the instrumental records of summer mass balance, researchers may gain a better understanding of how glaciers behave in the summer, which they can use to calibrate and verify their existing models.

From Tuesday 27 November, this paper can be downloaded from http://iopscience.iop.org/1748-9326/7/4/044031/article

###

Notes to Editors

Contact

1. For further information, a full draft of the journal paper or contact with one of the researchers, contact IOP Press Officer, Michael Bishop:
Tel: 0117 930 1032
E-mail: Michael.bishop@iop.org

Can shrubs help to reconstruct glacier retreats?

2. The published version of the paper 'Can shrubs help to reconstruct glacier retreats?' (Allan Buras et al 2012 Environ. Res. Lett. 7 044031) will be freely available online from Tuesday 27 November. It will be available at http://iopscience.iop.org/1748-9326/7/4/044031/article.

Environmental Research Letters

3. Environmental Research Letters is an open access journal that covers all of environmental science, providing a coherent and integrated approach including research articles, perspectives and editorials.

IOP Publishing

4. IOP Publishing provides publications through which leading-edge scientific research is distributed worldwide. IOP Publishing is central to the Institute of Physics (IOP), a not-for-profit society. Any financial surplus earned by IOP Publishing goes to support science through the activities of IOP. Beyond our traditional journals programme, we make high-value scientific information easily accessible through an ever-evolving portfolio of community websites, magazines, conference proceedings and a multitude of electronic services. Focused on making the most of new technologies, we're continually improving our electronic interfaces to make it easier for researchers to find exactly what they need, when they need it, in the format that suits them best. Go to http://ioppublishing.org/.

The Institute of Physics

5. The Institute of Physics is a leading scientific society. We are a charitable organisation with a worldwide membership of more than 45,000, working together to advance physics education, research and application. We engage with policymakers and the general public to develop awareness and understanding of the value of physics and, through IOP Publishing, we are world leaders in professional scientific communications.


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Shrubs lend an insight into a glacier's past [ Back to EurekAlert! ] Public release date: 26-Nov-2012
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Contact: Michael Bishop
michael.bishop@iop.org
01-179-301-032
Institute of Physics

The stems of shrubs have given researchers a window into a glacier's past, potentially allowing them to more accurately assess how they're set to change in the future.

Their findings have been published today, 27 November, in IOP Publishing's journal Environmental Research Letters, and show how a glacier's history of melting can be extended way past the instrumental record.

Much like the rings on a tree stump indicate how old it is, measuring the width of rings on the stem of a shrub can give a good indication of how well it has grown year on year. Under extreme environmental conditions, such as those close to a glacier, a shrub's growth relies heavily on summer temperatures, meaning the ring-width of a shrub can be used a proxy for glacial melting, which also relies heavily on summer temperatures.

Lead author of the study, Allan Buras, said: "In warm summers, shrubs grow more compared to cold summers. In contrast, a glacier's summer mass balance is more negative in warm summers, meaning there is more melting compared to cold summers.

"Big rings in shrubs therefore indicate comparably warm summers, and thus a strongly negative summer mass balance in other words, more melting."

The researchers, from the University of Greifswald, tested this theory on a local icecap in the Scandic Mountains of southern Norway. They took 24 samples of shrubs from a site close to the glacier and analysed their ring-widths.

Monthly precipitation and temperature data from a local climate station were retrieved from the Norwegian Meteorological Office, and the summer mass balance of the glacier, from 1963 to 2010, was retrieved from the existing literature.

Each of these data sets was then statistically tested to see if there was a correlation between them. The results showed a robust and reliable correlation between the ring-width of shrubs and the summer melting of the glacier.

"Our results show that it is possible to reconstruct glacier summer mass balance with shrub ring-width series and it is therefore theoretically possible to extent records of summer mass balance into the past," Buras continued.

The shrubs that were collected in the study were relatively young, only allowing for reliable reconstructions over the past 36 years, meaning they could not be used to extend the record of the glacier; however, the researchers are confident that this could have been achieved if longer-lived shrubs were selected.

Most of the available data on the mass balance of glaciers only spans several decades and there is some data missing, mainly because most glaciers are situated in hard-to-reach arctic and alpine areas.

With the possibility to extend the instrumental records of summer mass balance, researchers may gain a better understanding of how glaciers behave in the summer, which they can use to calibrate and verify their existing models.

From Tuesday 27 November, this paper can be downloaded from http://iopscience.iop.org/1748-9326/7/4/044031/article

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Notes to Editors

Contact

1. For further information, a full draft of the journal paper or contact with one of the researchers, contact IOP Press Officer, Michael Bishop:
Tel: 0117 930 1032
E-mail: Michael.bishop@iop.org

Can shrubs help to reconstruct glacier retreats?

2. The published version of the paper 'Can shrubs help to reconstruct glacier retreats?' (Allan Buras et al 2012 Environ. Res. Lett. 7 044031) will be freely available online from Tuesday 27 November. It will be available at http://iopscience.iop.org/1748-9326/7/4/044031/article.

Environmental Research Letters

3. Environmental Research Letters is an open access journal that covers all of environmental science, providing a coherent and integrated approach including research articles, perspectives and editorials.

IOP Publishing

4. IOP Publishing provides publications through which leading-edge scientific research is distributed worldwide. IOP Publishing is central to the Institute of Physics (IOP), a not-for-profit society. Any financial surplus earned by IOP Publishing goes to support science through the activities of IOP. Beyond our traditional journals programme, we make high-value scientific information easily accessible through an ever-evolving portfolio of community websites, magazines, conference proceedings and a multitude of electronic services. Focused on making the most of new technologies, we're continually improving our electronic interfaces to make it easier for researchers to find exactly what they need, when they need it, in the format that suits them best. Go to http://ioppublishing.org/.

The Institute of Physics

5. The Institute of Physics is a leading scientific society. We are a charitable organisation with a worldwide membership of more than 45,000, working together to advance physics education, research and application. We engage with policymakers and the general public to develop awareness and understanding of the value of physics and, through IOP Publishing, we are world leaders in professional scientific communications.


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Source: http://www.eurekalert.org/pub_releases/2012-11/iop-sla112212.php

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